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FIGNL2 fidgetin like 2 [ Homo sapiens (human) ]

Gene ID: 401720, updated on 2-Nov-2024

Summary

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Official Symbol
FIGNL2provided by HGNC
Official Full Name
fidgetin like 2provided by HGNC
Primary source
HGNC:HGNC:13287
See related
Ensembl:ENSG00000261308 MIM:620503; AllianceGenome:HGNC:13287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Involved in microtubule severing and negative regulation of cell migration. Located in cell leading edge. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney (RPKM 1.7), testis (RPKM 0.4) and 15 other tissues See more
Orthologs
mouse all
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Genomic context

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See FIGNL2 in Genome Data Viewer
Location:
12q13.13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (51817899..51848718, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (51781425..51812316, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52211683..52242502, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 8 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4473 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:52208409-52208908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52220360-52220860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52221534-52222085 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52223188-52223737 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52229864-52230815 Neighboring gene transmembrane and death domain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52238698-52239408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52239409-52240117 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:52240828-52241536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52241735-52242726 Neighboring gene FIGNL2 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52256788-52257308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52262827-52263460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52263461-52264092 Neighboring gene filamin-B-like Neighboring gene ankyrin repeat domain 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing. Charafeddine RA, et al. J Invest Dermatol, 2015 Sep. PMID 25756798, Free PMC Article
  2. Fidgetin-like 2 depletion enhances cell migration by regulating GEF-H1, RhoA, and FAK. Smart K, et al. Biophys J, 2023 Sep 19. PMID 36523161, Free PMC Article
  3. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. Cox GA, et al. Nat Genet, 2000 Oct. PMID 11017077
  4. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075
  5. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang P, et al. J Clin Invest, 2019 Jul 25. PMID 31343991, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fidgetin-like 2 depletion enhances cell migration by regulating GEF-H1, RhoA, and FAK.
    Title: Fidgetin-like 2 depletion enhances cell migration by regulating GEF-H1, RhoA, and FAK.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule severing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of a branching structure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of wound healing, spreading of epidermal cells ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fidgetin-like protein 2
Names
putative fidgetin-like protein 2
NP_001013712.4
NP_001371924.1
NP_001371925.1
XP_016874787.1
XP_016874788.1
XP_054228022.1
XP_054228023.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013690.5 → NP_001013712.4  fidgetin-like protein 2

    See identical proteins and their annotated locations for NP_001013712.4

    Status: VALIDATED

    Source sequence(s)
    AC068987
    Consensus CDS
    CCDS86302.1
    UniProtKB/Swiss-Prot
    A6NMB9
    Conserved Domains (2) summary
    pfam09336
    Location:614 → 650
    Vps4_C; Vps4 C terminal oligomerization domain
    cd19523
    Location:393 → 555
    RecA-like_fidgetin; ATPase domain of fidgetin

  2. NM_001384995.1 → NP_001371924.1  fidgetin-like protein 2

    Status: VALIDATED

    Source sequence(s)
    AC068987
    Consensus CDS
    CCDS86302.1
    UniProtKB/Swiss-Prot
    A6NMB9
    Related
    ENSP00000491257.1, ENST00000618634.3
    Conserved Domains (2) summary
    pfam09336
    Location:614 → 650
    Vps4_C; Vps4 C terminal oligomerization domain
    cd19523
    Location:393 → 555
    RecA-like_fidgetin; ATPase domain of fidgetin

  3. NM_001384996.1 → NP_001371925.1  fidgetin-like protein 2

    Status: VALIDATED

    Source sequence(s)
    AC068987
    Consensus CDS
    CCDS86302.1
    UniProtKB/Swiss-Prot
    A6NMB9
    Conserved Domains (2) summary
    pfam09336
    Location:614 → 650
    Vps4_C; Vps4 C terminal oligomerization domain
    cd19523
    Location:393 → 555
    RecA-like_fidgetin; ATPase domain of fidgetin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    51817899..51848718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019299.2 → XP_016874788.1  fidgetin-like protein 2 isoform X2

  2. XM_017019298.2 → XP_016874787.1  fidgetin-like protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    51781425..51812316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372048.1 → XP_054228023.1  fidgetin-like protein 2 isoform X2

  2. XM_054372047.1 → XP_054228022.1  fidgetin-like protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NMB9.2 GenPept UniProtKB/Swiss-Prot:A6NMB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials