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C5orf63 chromosome 5 open reading frame 63 [ Homo sapiens (human) ]

Gene ID: 401207, updated on 2-Nov-2024

Summary

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Official Symbol
C5orf63provided by HGNC
Official Full Name
chromosome 5 open reading frame 63provided by HGNC
Primary source
HGNC:HGNC:40051
See related
Ensembl:ENSG00000164241 AllianceGenome:HGNC:40051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YDR286C
Summary
Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 1.4), lymph node (RPKM 0.9) and 25 other tissues See more
Orthologs
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Genomic context

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See C5orf63 in Genome Data Viewer
Location:
5q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (127042562..127073502, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (127562642..127593579, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (126378254..126409194, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126211055-126211554 Neighboring gene membrane associated ring-CH-type finger 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126231155-126231764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126366588-126367132 Neighboring gene uncharacterized LOC105379163 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126376473-126377316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16290 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:126412476-126413058 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:126415384-126416305 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:126431231-126431730 Neighboring gene NANOG hESC enhancer GRCh37_chr5:126432239-126432781 Neighboring gene mitochondrial ribosomal protein S5 pseudogene 3 Neighboring gene RNA-binding protein 15-like Neighboring gene selenoprotein T pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44606

General protein information

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Preferred Names
glutaredoxin-like protein C5orf63
Names
glutaredoxin-like protein YDR286C homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164478.2 → NP_001157950.1  glutaredoxin-like protein C5orf63 isoform 2

    See identical proteins and their annotated locations for NP_001157950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon with a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005915
    Consensus CDS
    CCDS54896.1
    UniProtKB/Swiss-Prot
    A6NC05
    Related
    ENSP00000453964.1, ENST00000296662.10
    Conserved Domains (1) summary
    pfam05768
    Location:33 → 106
    DUF836; Glutaredoxin-like domain (DUF836)

  2. NM_001164479.2 → NP_001157951.1  glutaredoxin-like protein C5orf63 isoform 1

    See identical proteins and their annotated locations for NP_001157951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AC004507, AC005915, BQ269742, DA507232
    Consensus CDS
    CCDS54895.1
    UniProtKB/Swiss-Prot
    A6NC05, G3V557
    Related
    ENSP00000454153.1, ENST00000535381.6
    Conserved Domains (1) summary
    cl00388
    Location:33 → 60
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. NM_001388304.1 → NP_001375233.1  glutaredoxin-like protein C5orf63 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005915
    Consensus CDS
    CCDS93776.1
    UniProtKB/TrEMBL
    A0A8C8V477
    Related
    ENSP00000475810.2, ENST00000606937.6
    Conserved Domains (1) summary
    cl00388
    Location:33 → 76
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  4. NM_001388305.1 → NP_001375234.1  glutaredoxin-like protein C5orf63 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC005915
    Consensus CDS
    CCDS93775.1
    UniProtKB/TrEMBL
    U3KQR4
    Related
    ENSP00000476160.1, ENST00000607731.5
    Conserved Domains (1) summary
    cl00388
    Location:33 → 53
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RNA

  1. NR_170930.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004507, AC005915

  2. NR_170931.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004507, AC005915

  3. NR_170932.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005915

  4. NR_170933.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005915

  5. NR_170934.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005915

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    127042562..127073502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007058603.1 RNA Sequence

  2. XR_007058602.1 RNA Sequence

  3. XR_007058601.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    127562642..127593579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487118.1 RNA Sequence

  2. XR_008487117.1 RNA Sequence

  3. XR_008487116.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NC05.3 GenPept UniProtKB/Swiss-Prot:A6NC05

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