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FOXL2NB FOXL2 neighbor [ Homo sapiens (human) ]

Gene ID: 401089, updated on 2-Nov-2024

Summary

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Official Symbol
FOXL2NBprovided by HGNC
Official Full Name
FOXL2 neighborprovided by HGNC
Primary source
HGNC:HGNC:34428
See related
Ensembl:ENSG00000206262 AllianceGenome:HGNC:34428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf72
Summary
Located in fibrillar center. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in ovary (RPKM 15.2) and endometrium (RPKM 8.8) See more
Orthologs
all
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Genomic context

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See FOXL2NB in Genome Data Viewer
Location:
3q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (138947217..138953990)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (141688060..141694996)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138666059..138672832)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3980 Neighboring gene long intergenic non-protein coding RNA 1391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:138663365-138663954 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:138665995-138666223 Neighboring gene forkhead box L2 Neighboring gene proline rich 23A Neighboring gene proline rich 23B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. New STAT3-FOXL2 pathway and its function in cancer cells. Han Y, et al. BMC Mol Cell Biol, 2019 Jun 20. PMID 31221094, Free PMC Article
  2. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ52231

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
FOXL2 neighbor protein
Names
FLJ43329 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029796.1 RefSeqGene

    Range
    4984..11757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040061.3 → NP_001035150.1  FOXL2 neighbor protein

    See identical proteins and their annotated locations for NP_001035150.1

    Status: VALIDATED

    Source sequence(s)
    AC092947, AC130416, AK125319
    Consensus CDS
    CCDS43155.1
    UniProtKB/Swiss-Prot
    A6NGX0, Q6ZUU3
    Related
    ENSP00000372651.3, ENST00000383165.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    138947217..138953990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247443.4 → XP_005247500.1  FOXL2 neighbor protein isoform X2

  2. XM_024453517.2 → XP_024309285.1  FOXL2 neighbor protein isoform X1

    UniProtKB/TrEMBL
    B7Z962
    Conserved Domains (1) summary
    cl26247
    Location:106 → 185
    DNA_pol3_delta2; DNA polymerase III, delta subunit

  3. XM_024453518.2 → XP_024309286.1  FOXL2 neighbor protein isoform X1

    UniProtKB/TrEMBL
    B7Z962
    Conserved Domains (1) summary
    cl26247
    Location:106 → 185
    DNA_pol3_delta2; DNA polymerase III, delta subunit

  4. XM_047448095.1 → XP_047304051.1  FOXL2 neighbor protein isoform X1

    UniProtKB/TrEMBL
    B7Z962

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    141688060..141694996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346486.1 → XP_054202461.1  FOXL2 neighbor protein isoform X2

  2. XM_054346484.1 → XP_054202459.1  FOXL2 neighbor protein isoform X1

  3. XM_054346483.1 → XP_054202458.1  FOXL2 neighbor protein isoform X1

  4. XM_054346485.1 → XP_054202460.1  FOXL2 neighbor protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZUU3.1 GenPept UniProtKB/Swiss-Prot:Q6ZUU3

Gene LinkOut

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Molecular Biology Databases
Research Materials