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nes nessy [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40093, updated on 2-Nov-2024

Summary

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Official Symbol
nesprovided by FlyBase
Official Full Name
nessyprovided by FlyBase
Primary source
FLYBASE:FBgn0026630
Locus tag
Dmel_CG9655
See related
AllianceGenome:FB:FBgn0026630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9655; Dmel\CG9655; Nes
Summary
Enables lysophospholipid acyltransferase activity. Involved in several processes, including germ cell migration; lipid modification; and sperm individualization. Located in membrane. Is expressed in several structures, including adult head; cephalic furrow; germ layer; germline cell; and mesectoderm anlage. Orthologous to human LPCAT3 (lysophosphatidylcholine acyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See nes in Genome Data Viewer
Location:
76A3-76A3; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19257282..19260679, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19250382..19253779, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene reptin Neighboring gene antisense RNA:CR45210 Neighboring gene Blocked early in transport 1 Neighboring gene Max Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 5 Neighboring gene uncharacterized protein Neighboring gene Aldehyde dehydrogenase 7 family member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. nessy, an evolutionary conserved gene controlled by Hox proteins during Drosophila embryogenesis. Maurel-Zaffran C, et al. Mech Dev, 1999 Aug. PMID 10446276
  2. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Steinhauer J, et al. Mol Biol Cell, 2009 Dec. PMID 19864461, Free PMC Article
  3. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
  4. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
  5. Drosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA. Yuan X, et al. Cell Death Dis, 2019 Feb 11. PMID 30741974, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in germ cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sperm individualization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nessy
Names
CG9655-PA
CG9655-PB
CG9655-PC
nes-PA
nes-PB
nes-PC
NP_524157.2
NP_730390.1
NP_788527.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19257282..19260679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079433.3 → NP_524157.2  nessy, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524157.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V238, Q9VVX5, Q9XYV9
    Related
    FBpp0074786
    Conserved Domains (1) summary
    pfam03062
    Location:114 → 421
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  2. NM_176349.2 → NP_788527.1  nessy, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V238, Q9VVX5, Q9XYV9
    Related
    FBpp0074788
    Conserved Domains (1) summary
    pfam03062
    Location:114 → 421
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  3. NM_168788.3 → NP_730390.1  nessy, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730390.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V238, Q9VVX5, Q9XYV9
    Related
    FBpp0074787
    Conserved Domains (1) summary
    pfam03062
    Location:114 → 421
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVX5.1 Q9VVX5

Gene LinkOut

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