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MIR137HG MIR137 host gene [ Homo sapiens (human) ]

Gene ID: 400765, updated on 12-Nov-2024

Summary

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Official Symbol
MIR137HGprovided by HGNC
Official Full Name
MIR137 host geneprovided by HGNC
Primary source
HGNC:HGNC:42871
See related
Ensembl:ENSG00000225206 AllianceGenome:HGNC:42871
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See MIR137HG in Genome Data Viewer
Location:
1p21.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (97988000..98049693, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (97835839..97897607, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (98453556..98515249, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1930 Neighboring gene uncharacterized LOC124904227 Neighboring gene uncharacterized LOC124904228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1110 Neighboring gene uncharacterized LOC124900404 Neighboring gene microRNA 2682 Neighboring gene microRNA 137 Neighboring gene NANOG hESC enhancer GRCh37_chr1:98552438-98552987 Neighboring gene NFU1 iron-sulfur cluster scaffold pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:98670662-98671305 Neighboring gene long intergenic non-protein coding RNA 1776

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Impact of MIR137HG rs7554283 on susceptibility to high-altitude pulmonary edema in the Chinese population. Xu S, et al. Per Med, 2024. PMID 39439230
  2. The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population. Guo Y, et al. Gene, 2021 Dec 15. PMID 34403773
  3. Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls. Zhang Z, et al. Neuroimage Clin, 2018. PMID 30035013, Free PMC Article
  4. MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia. Patel VS, et al. Neurosci Lett, 2015 Aug 18. PMID 26123324, Free PMC Article
  5. Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia. Wright C, et al. Transl Psychiatry, 2016 Feb 2. PMID 26836412, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of MIR137HG rs7554283 on susceptibility to high-altitude pulmonary edema in the Chinese population.
    Title: Impact of MIR137HG rs7554283 on susceptibility to high-altitude pulmonary edema in the Chinese population.
  2. miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer.
    Title: miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer.
  3. Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients.
    Title: Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients.
  4. The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population.
    Title: The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population.
  5. Blood and tissue levels of lncRNAs in periodontitis.
    Title: Blood and tissue levels of lncRNAs in periodontitis.
  6. decreased white matter integrity of the posterior cingulum in risk allele homozygotes of MIR137
    Title: Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls.
  7. Single-nucleotide polymorphism (SNP), rs1625579, within the host gene (MIR137HG) was identified as the top new associated SNP in the first large schizophrenia genome-wide association study.
    Title: Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia.
  8. the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.
    Title: MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association study identifies five new schizophrenia loci.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • MIR137 host gene (non-protein coding)

Clone Names

  • FLJ35409

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046105.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK094607, BX005019, DA791600
    Related
    ENST00000424528.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    97988000..98049693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    97835839..97897607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001688.1: Suppressed sequence

    Description
    NM_001001688.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials