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MYO18A myosin XVIIIA [ Homo sapiens (human) ]

Gene ID: 399687, updated on 14-Nov-2024

Summary

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Official Symbol
MYO18Aprovided by HGNC
Official Full Name
myosin XVIIIAprovided by HGNC
Primary source
HGNC:HGNC:31104
See related
Ensembl:ENSG00000196535 MIM:609517; MIM:610067; AllianceGenome:HGNC:31104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAJN; TIAF1; MYSPDZ; SPR210; SP-R210
Summary
The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]
Annotation information
Note: This gene is now merged into MYO18A (GeneID:399687) due to overlap of a significant portion of the transcript with 3' terminal exon of MYO18A. [10 Jan 2022]
Expression
Ubiquitous expression in skin (RPKM 21.0), bone marrow (RPKM 16.2) and 25 other tissues See more
Orthologs
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Genomic context

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See MYO18A in Genome Data Viewer
Location:
17q11.2
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (29071122..29180398, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (30013842..30123093, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27398140..27507416, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 7 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:27359363-27360197 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27369638-27370526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27381450-27382004 Neighboring gene pipecolic acid and sarcosine oxidase Neighboring gene Sharpr-MPRA regulatory region 1762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27423404-27423904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27423905-27424405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27429751-27430716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27435597-27436179 Neighboring gene Sharpr-MPRA regulatory region 1183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27454495-27455030 Neighboring gene Sharpr-MPRA regulatory region 390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27464737-27465720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27465721-27466704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8364 Neighboring gene uncharacterized LOC124903967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11967 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:27481880-27483079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8367 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:27507275-27507495 Neighboring gene gap junction protein alpha 4 pseudogene Neighboring gene twinfilin 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells. van der Leij J, et al. Transplantation, 2003 Jun 27. PMID 12829915
  2. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. Isogawa Y, et al. Biochemistry, 2005 Apr 26. PMID 15835906
  3. Binding of the extreme carboxyl-terminus of PAK-interacting exchange factor β (βPIX) to myosin 18A (MYO18A) is required for epithelial cell migration. Hsu RM, et al. Biochim Biophys Acta, 2014 Nov. PMID 25014165
  4. MYO18A: An unusual myosin. Buschman MD, et al. Adv Biol Regul, 2018 Jan. PMID 28942352, Free PMC Article
  5. Proteomics analysis of the ezrin interactome in B cells reveals a novel association with Myo18aα. Matsui K, et al. J Proteome Res, 2011 Sep 2. PMID 21751808, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages.
    Title: SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages.
  2. Expression of TIAF-1 in the lymphocytes during chronic allograft rejection may be related to the predominance of a Th2 response in this condition and may protect these cells from apoptosis
    Title: High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells.
  3. TIAF1 and p53 functionally interact in regulating apoptosis, and TIAF1 is likely to participate in the nuclear translocation of activated p53.
    Title: TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.
  4. In vitro induction of TIAF1 self-association upregulated the expression of tumor suppressors Smad4 and WW domain-containing oxidoreductase (WOX1 or WWOX), and WOX1 in turn increased the TIAF1 expression.
    Title: TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
  5. TIAF1 undergoes self-aggregation in response to TGF-Beta1.
    Title: TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.
  6. a high proportion of MYO18A is found in complex with GOLPH3 at the trans Golgi, where it functions to promote vesicle budding for Golgi-to-plasma membrane trafficking.
    Title: MYO18A: An unusual myosin.
  7. Studies indicate that MYO18A is overexpressed in metastatic prostate cancer (PC-3) cells.
    Title: How myosin organization of the actin cytoskeleton contributes to the cancer phenotype.
  8. Identification of the DNA-damage-induced Golgi response reveals an unexpected pathway through DNA-PK, GOLPH3, and MYO18A that regulates cell survival following DNA damage.
    Title: DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.
  9. PDZ module mediates direct binding of myosin-18A to GOLPH3, and this interaction in turn modulates the actin binding properties of the N-terminal extension. Thus, myosin-18A can act as an actin cross-linker with multiple regulatory modulators
    Title: Functional characterization of human myosin-18A and its interaction with F-actin and GOLPH3.
  10. GOLPH3L differs critically from GOLPH3 in that it is largely unable to bind to MYO18A; data demonstrate that despite their similarities, unexpectedly, GOLPH3L antagonizes GOLPH3/MYO18A at the Golgi
    Title: GOLPH3L antagonizes GOLPH3 to determine Golgi morphology.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of myosin XVIIIA (MYO18A) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30396, FLJ44913, KIAA0216, DKFZp686L0243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi vesicle budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in asymmetric Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of opsonization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in actomyosin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
unconventional myosin-XVIIIa
Names
12 kDa TGF-beta-1-induced antiapoptotic factor
Putative TGFB1-induced anti-apoptotic factor 1
SP-A receptor subunit SP-R210 alphaS
TGF-beta-1-induced antiapoptotic factor 1
TGFB1-induced anti-apoptotic factor 1
molecule associated with JAK3 N-terminus
molecule associated with Jak-3 N-terminal
myosin 18A
myosin containing PDZ domain
myosin containing a PDZ domain
surfactant protein receptor SP-R210

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051989.2 RefSeqGene

    Range
    37329..146605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346765.2 → NP_001333694.1  unconventional myosin-XVIIIa isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC005412, AC024619

  2. NM_001346766.2 → NP_001333695.1  unconventional myosin-XVIIIa isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AC005412, AC024619
    Consensus CDS
    CCDS92285.1
    UniProtKB/TrEMBL
    A0A994J771
    Related
    ENSP00000515984.1, ENST00000704659.1
    Conserved Domains (3) summary
    COG5022
    Location:393 → 1917
    COG5022; Myosin heavy chain [General function prediction only]
    cd00992
    Location:218 → 308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01386
    Location:431 → 1185
    MYSc_Myo18; class XVIII myosin, motor domain

  3. NM_001346767.2 → NP_001333696.1  unconventional myosin-XVIIIa isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks three alternate in-frame exons compared to variant 3. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AC005412, AC024619, BC039612
    Consensus CDS
    CCDS86587.1
    UniProtKB/Swiss-Prot
    Q92614
    Related
    ENSP00000435932.1, ENST00000533112.5

  4. NM_001346768.2 → NP_001333697.1  unconventional myosin-XVIIIa isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon and represents use of an alternate promoter, therefore differing in the 5' UTR and 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in an isoform (f) that lacks an alternate internal segment and has a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AC024619
    UniProtKB/TrEMBL
    B4DYM1

  5. NM_078471.4 → NP_510880.2  unconventional myosin-XVIIIa isoform a

    See identical proteins and their annotated locations for NP_510880.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate in-frame exon and lacks two alternate in-frame exons compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AC005412, AC024619, BM544214, D86970
    Consensus CDS
    CCDS45642.1
    UniProtKB/Swiss-Prot
    Q5H9U3, Q5QD01, Q5W9F9, Q5W9G1, Q8IXP8, Q92614
    Related
    ENSP00000437073.1, ENST00000527372.7
    Conserved Domains (7) summary
    smart00242
    Location:400 → 1185
    MYSc; Myosin. Large ATPases
    cd00992
    Location:218 → 308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01386
    Location:419 → 1173
    MYSc_Myo18; class XVIII myosin, motor domain
    pfam00038
    Location:1258 → 1583
    Filament; Intermediate filament protein
    pfam09755
    Location:1558 → 1910
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    pfam16043
    Location:1756 → 1898
    DUF4795; Domain of unknown function (DUF4795)
    cl02488
    Location:1389 → 1628
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. NM_203318.2 → NP_976063.1  unconventional myosin-XVIIIa isoform b

    See identical proteins and their annotated locations for NP_976063.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AC005412, AC024619, AF252258, BM544214, D86970
    Consensus CDS
    CCDS45641.1
    Related
    ENSP00000434228.1, ENST00000531253.5
    Conserved Domains (3) summary
    COG5022
    Location:381 → 1905
    COG5022; Myosin heavy chain [General function prediction only]
    cd00992
    Location:218 → 308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01386
    Location:419 → 1173
    MYSc_Myo18; class XVIII myosin, motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    29071122..29180398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    30013842..30123093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004740.3: Suppressed sequence

    Description
    NM_004740.3: This RefSeq was removed because the gene is thought to be a part of the 3' end of another gene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95411.2 GenPept UniProtKB/Swiss-Prot:O95411
Q92614.3 GenPept UniProtKB/Swiss-Prot:Q92614

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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