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Flrt2 fibronectin leucine rich transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 399558, updated on 2-Nov-2024

Summary

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Official Symbol
Flrt2provided by MGI
Official Full Name
fibronectin leucine rich transmembrane protein 2provided by MGI
Primary source
MGI:MGI:3603594
See related
Ensembl:ENSMUSG00000047414 AllianceGenome:MGI:3603594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in basement membrane organization; cell adhesion involved in heart morphogenesis; and fibroblast growth factor receptor signaling pathway. Acts upstream of or within axon guidance; positive regulation of synapse assembly; and regulation of neuron migration. Located in cell-cell junction; extracellular space; and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 8.9), CNS E14 (RPKM 5.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Flrt2 in Genome Data Viewer
Location:
12 E; 12 46.44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (95658780..95751989)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (95692006..95785215)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32973 Neighboring gene predicted gene, 22246 Neighboring gene ribosomal protein L17, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32974 Neighboring gene STARR-seq mESC enhancer starr_32975 Neighboring gene RIKEN cDNA 1700019M22 gene Neighboring gene STARR-seq mESC enhancer starr_32976 Neighboring gene STARR-seq mESC enhancer starr_32977 Neighboring gene STARR-seq mESC enhancer starr_32978 Neighboring gene STARR-seq mESC enhancer starr_32979 Neighboring gene STARR-seq mESC enhancer starr_32980 Neighboring gene STARR-seq mESC enhancer starr_32981 Neighboring gene STARR-seq mESC enhancer starr_32982 Neighboring gene nascent polypeptide-associated complex alpha polypeptide pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis. Fang Y, et al. Front Immunol, 2023. PMID 37090697, Free PMC Article
  2. FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis. Xu Y, et al. J Cell Biochem, 2011 Nov. PMID 21769912
  3. FLRT2 interacts with fibronectin in the ATDC5 chondroprogenitor cells. Flintoff KA, et al. J Cell Physiol, 2014 Oct. PMID 24585683
  4. Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness. Ando T, et al. J Clin Invest, 2022 Mar 15. PMID 35104247, Free PMC Article
  5. Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice. Cicvaric A, et al. Sci Rep, 2018 Feb 27. PMID 29487336, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
    Title: FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
  2. Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis.
    Title: Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis.
  3. Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.
    Title: Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.
  4. FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
    Title: FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
  5. The Flrt2 regulates osteoclast multinucleation by interfering with Netrin 1-Unc5b interaction and may be a suitable therapeutic target for diseases associated with bone remodeling.
    Title: Flrt2 is involved in fine-tuning of osteoclast multinucleation.
  6. The observations propose that FLRT2 can regulate memory functions in the adulthood in a sex-specific manner and might thus contribute to further research on the mechanisms linking sexual dimorphism and cognition.
    Title: Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice.
  7. fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.
    Title: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.
  8. Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion.
    Title: Super-complexes of adhesion GPCRs and neural guidance receptors.
  9. FLRT2 may exist in both membrane-bound and shed forms which interact with fibronectin in the ATDC5 chondroprogenitor cells.
    Title: FLRT2 interacts with fibronectin in the ATDC5 chondroprogenitor cells.
  10. findings provide evidence for a role of FLRT2 in enhancing cell proliferation and reducing intercellular adhesion during the early stages of chondrogenesis
    Title: FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0405

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of postsynapse assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat transmembrane protein FLRT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001422812.1 → NP_001409741.1  leucine-rich repeat transmembrane protein FLRT2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122430, AC125487
    UniProtKB/Swiss-Prot
    Q6A073, Q8BLU0
    Related
    ENSMUSP00000105744.2, ENSMUST00000110117.2

  2. NM_201518.4 → NP_958926.1  leucine-rich repeat transmembrane protein FLRT2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_958926.1

    Status: VALIDATED

    Source sequence(s)
    AC122430, AC125487
    Consensus CDS
    CCDS26094.1
    UniProtKB/Swiss-Prot
    Q6A073, Q8BLU0
    UniProtKB/TrEMBL
    Q3UVS6
    Related
    ENSMUSP00000062171.4, ENSMUST00000057324.4
    Conserved Domains (6) summary
    PRK15370
    Location:26 → 265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282 → 359
    PCC; polycystin cation channel protein
    sd00031
    Location:65 → 86
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90 → 110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426 → 494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252 → 311
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    95658780..95751989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244132.3 → XP_011242434.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    See identical proteins and their annotated locations for XP_011242434.1

    UniProtKB/Swiss-Prot
    Q6A073, Q8BLU0
    UniProtKB/TrEMBL
    Q3UVS6
    Conserved Domains (6) summary
    PRK15370
    Location:26 → 265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282 → 359
    PCC; polycystin cation channel protein
    sd00031
    Location:65 → 86
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90 → 110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426 → 494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252 → 311
    LRR_8; Leucine rich repeat

  2. XM_036157517.1 → XP_036013410.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    UniProtKB/Swiss-Prot
    Q6A073, Q8BLU0
    UniProtKB/TrEMBL
    Q3UVS6
    Conserved Domains (6) summary
    PRK15370
    Location:26 → 265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282 → 359
    PCC; polycystin cation channel protein
    sd00031
    Location:65 → 86
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90 → 110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426 → 494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252 → 311
    LRR_8; Leucine rich repeat

  3. XM_036157518.1 → XP_036013411.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    UniProtKB/Swiss-Prot
    Q6A073, Q8BLU0
    UniProtKB/TrEMBL
    Q3UVS6
    Conserved Domains (6) summary
    PRK15370
    Location:26 → 265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282 → 359
    PCC; polycystin cation channel protein
    sd00031
    Location:65 → 86
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90 → 110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426 → 494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252 → 311
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLU0.1 GenPept UniProtKB/Swiss-Prot:Q8BLU0

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