tcf12.L transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tcf12.L
Official Full Name: transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) L homeolog
Primary source: Xenbase:XB-GENE-5799717
Locus tag: XELAEV_18018173mg
See related: EnsemblRapid:ENSXLAG00005002940 AllianceGenome:Xenbase:XB-GENE-5799717
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: HEB; tcf12
Summary: Predicted to enable E-box binding activity and protein heterodimerization activity. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in craniosynostosis and hypogonadotropic hypogonadism. Orthologous to human TCF12 (transcription factor 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (105307096..105441036, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (89964264..90096797, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor XE1.1

Names: Transcription factor XE1.1; XE1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

105307096..105441036 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041586765.1 → XP_041442699.1 transcription factor XE1.1 isoform X1

UniProtKB/TrEMBL

A0A8J0US90, Q641A7

Conserved Domains (1) summary

cd18945
Location:598 → 682

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_018253035.2 → XP_018108524.1 transcription factor XE1.1 isoform X2

UniProtKB/TrEMBL

A0A8J0UVG2, Q641A7
XM_018253037.2 → XP_018108526.1 transcription factor XE1.1 isoform X3

UniProtKB/TrEMBL

A0A8J0UJZ2, Q641A7
XM_018253038.2 → XP_018108527.1 transcription factor XE1.1 isoform X4

UniProtKB/TrEMBL

A0A1L8H0C5, A0A974DEN2, Q641A7
XM_018253033.2 → XP_018108522.1 transcription factor XE1.1 isoform X1

UniProtKB/TrEMBL

A0A8J0US90, Q641A7

Conserved Domains (1) summary

cd18945
Location:598 → 682

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_018253036.2 → XP_018108525.1 transcription factor XE1.1 isoform X2

UniProtKB/TrEMBL

A0A8J0UVG2, Q641A7
XM_041586766.1 → XP_041442700.1 transcription factor XE1.1 isoform X7

UniProtKB/TrEMBL

A0A8J1MNT2, Q641A7

Conserved Domains (1) summary

cd18945
Location:535 → 619

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_041586767.1 → XP_041442701.1 transcription factor XE1.1 isoform X8

UniProtKB/TrEMBL

A0A8J1MMQ0

Conserved Domains (1) summary

cd18945
Location:367 → 451

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_018253039.2 → XP_018108528.1 transcription factor XE1.1 isoform X5

UniProtKB/TrEMBL

A0A8J0US92

Related

ENSXLAP00005008787.1, ENSXLAT00005008913.1
XM_018253041.2 → XP_018108530.1 transcription factor XE1.1 isoform X6

UniProtKB/TrEMBL

A0A8J0US51