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pou2f1.S POU class 2 homeobox 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399316, updated on 18-Sep-2024

Summary

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Official Symbol
pou2f1.S
Official Full Name
POU class 2 homeobox 1 S homeolog
Primary source
Xenbase:XB-GENE-853997
Locus tag
XELAEV_18014401mg
See related
EnsemblRapid:ENSXLAG00005033216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
oct1; NF-A1; oct-1; pou2f1; oct1.32; pou2f1r
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Genomic context

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See pou2f1.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (24935579..25025703)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (24845032..24957358)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694831.1 (1517724..1518466, complement)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene glycoprotein A33 (transmembrane) S homeolog Neighboring gene serine/threonine/tyrosine-interacting-like protein 2 Neighboring gene serine/threonine/tyrosine-interacting-like protein 2 Neighboring gene CD247 molecule S homeolog Neighboring gene uncharacterized LOC108709274 Neighboring gene RCSD domain containing 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The POU homeobox protein Oct-1 regulates radial glia formation downstream of Notch signaling. Kiyota T, et al. Dev Biol, 2008 Mar 15. PMID 18241856
  2. Non-cell autonomous induction of apoptosis and loss of posterior structures by activation domain-specific interactions of Oct-1 in the Xenopus embryo. Veenstra GJ, et al. Cell Death Differ, 1998 Sep. PMID 10200537
  3. Dynamic and differential Oct-1 expression during early Xenopus embryogenesis: persistence of Oct-1 protein following down-regulation of the RNA. Veenstra GJ, et al. Mech Dev, 1995 Apr. PMID 7542467
  4. Nucleotide sequence of Xenopus laevis Oct-1 cDNA. Smith DP, et al. Nucleic Acids Res, 1990 Jan 25. PMID 2326173, Free PMC Article
  5. Xenopus laevis Oct-1 does not bind to certain histone H2B gene promoter octamer motifs for which a novel octamer-binding factor has high affinity. Smith DP, et al. Nucleic Acids Res, 1991 Feb 25. PMID 2017364, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified Oct-1 (POU2f1), a POU transcription factor, as a downstream target of Notch signaling by microarray based screen
    Title: The POU homeobox protein Oct-1 regulates radial glia formation downstream of Notch signaling.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
POU domain, class 2, transcription factor 1
Names
OTF-1
XOct1
Xl-oct-1 protein
Xl-pou protein
maternal transcription factor
octamer-binding protein 1
octamer-binding transcription factor 1
xloct1-32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101785.2 → NP_001095255.1  POU domain, class 2, transcription factor 1

    See identical proteins and their annotated locations for NP_001095255.1

    Status: VALIDATED

    Source sequence(s)
    DC131858, X57165
    UniProtKB/Swiss-Prot
    P16143, Q01236, Q91809
    UniProtKB/TrEMBL
    A0A974DHU8
    Related
    ENSXLAP00005099850.1, ENSXLAT00005101784.1
    Conserved Domains (2) summary
    smart00352
    Location:294 → 368
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:398 → 451
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    24935579..25025703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041583052.1 → XP_041438986.1  POU domain, class 2, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A1L8H5R3, A0A974DHU8, A0A974HVE4
    Related
    ENSXLAP00005099653.1, ENSXLAT00005101571.1
    Conserved Domains (3) summary
    smart00352
    Location:294 → 367
    POU; Found in Pit-Oct-Unc transcription factors
    COG5576
    Location:382 → 498
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:400 → 454
    Homeobox; Homeobox domain

  2. XM_041583054.1 → XP_041438988.1  POU domain, class 2, transcription factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A1L8H5I6, A0A974DHU8, A0A974HUY4
    Conserved Domains (2) summary
    smart00352
    Location:294 → 368
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:398 → 452
    Homeobox; Homeobox domain

  3. XM_041583055.1 → XP_041438989.1  POU domain, class 2, transcription factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8J1MBA8, A0A974DHU8
    Conserved Domains (3) summary
    smart00352
    Location:275 → 348
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:378 → 434
    HOX; Homeodomain
    COG5576
    Location:363 → 479
    COG5576; Homeodomain-containing transcription factor [Transcription]

  4. XM_041583051.1 → XP_041438985.1  POU domain, class 2, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MD23, A0A974DHU8
    Conserved Domains (3) summary
    smart00352
    Location:296 → 369
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:399 → 455
    HOX; Homeodomain
    COG5576
    Location:384 → 500
    COG5576; Homeodomain-containing transcription factor [Transcription]

  5. XM_041583053.1 → XP_041438987.1  POU domain, class 2, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8J1MBA7, A0A974DHU8
    Related
    ENSXLAP00005100077.1, ENSXLAT00005102029.1
    Conserved Domains (2) summary
    smart00352
    Location:296 → 370
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:397 → 453
    HOX; Homeodomain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16143.3 GenPept UniProtKB/Swiss-Prot:P16143

Gene LinkOut

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Molecular Biology Databases
Research Materials