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cpeb1.L cytoplasmic polyadenylation element binding protein 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399289, updated on 4-Nov-2024

Summary

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Official Symbol
cpeb1.L
Official Full Name
cytoplasmic polyadenylation element binding protein 1 L homeolog
Primary source
Xenbase:XB-GENE-946172
Locus tag
XELAEV_18018089mg
See related
EnsemblRapid:ENSXLAG00005036365 AllianceGenome:Xenbase:XB-GENE-946172
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
CPEB; cpeb1; Cpeb-1; cpeb1-a; cpeb1-b
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity and mRNA regulatory element binding translation repressor activity. Acts upstream of or within midbrain development and neural precursor cell proliferation. Part of ribonucleoprotein complex. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cpeb1.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (100129026..100171794, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (84822773..84865428, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA71 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene ribosomal protein S17 L homeolog Neighboring gene AP-3 complex subunit beta-2 Neighboring gene ornithine decarboxylase antizyme 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein. Paris J, et al. Genes Dev, 1991 Sep. PMID 1653174
  2. Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mendez R, et al. Mol Cell, 2000 Nov. PMID 11106762
  3. CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome. Reverte CG, et al. Dev Biol, 2001 Mar 15. PMID 11237472
  4. Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction. Mendez R, et al. EMBO J, 2002 Apr 2. PMID 11927567, Free PMC Article
  5. Translational control of the embryonic cell cycle. Groisman I, et al. Cell, 2002 May 17. PMID 12086604

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-15/16 and CPEB co-regulate cyclin E1 mRNA.
    Title: CPEB and miR-15/16 Co-Regulate Translation of Cyclin E1 mRNA during Xenopus Oocyte Maturation.
  2. Pin1 is an essential factor regulating CPEB degradation
    Title: An unusual two-step control of CPEB destruction by Pin1.
  3. Data show that CPEB1 mRNA transcripts are present at low levels in RGCs but, surprisingly, CPEB1 protein was not detected in eye or brain tissue, and CPEB1 loss-of-function does not affect chemotropic responses or pathfinding in vivo.
    Title: Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.
  4. affects experience-dependent neuronal development and circuit formation in the visual system of Xenopus laevis
    Title: The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo.
  5. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b
    Title: CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.
  6. Xenopus Gef (XGef), a Rho-family guanine-exchange factor, influences the activating phosphorylation of CPEB.
    Title: MAPK interacts with XGef and is required for CPEB activation during meiosis in Xenopus oocytes.
  7. These results demonstrate that a reversible Pum2 interaction controls RINGO/Spy mRNA translation and, as a result, CPEB-mediated cytoplasmic polyadenylation
    Title: Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation.
  8. CPEB is not required for regulation of early class maternal mRNA translational activation in Xenopus oocytes
    Title: Cytoplasmic polyadenylation element (CPE)- and CPE-binding protein (CPEB)-independent mechanisms regulate early class maternal mRNA translational activation in Xenopus oocytes.
  9. XGef is involved in early CPEB activation with GTPase signaling
    Title: XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA regulatory element binding translation repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation factor activity, RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within midbrain development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytoplasmic translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cytoplasmic translation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytoplasmic polyadenylation element-binding protein 1-A
Names
58 kDa CPE-binding protein
CPE-BP1-A
CPE-binding protein 1-A
CPEB-1-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090603.1 → NP_001084072.1  cytoplasmic polyadenylation element-binding protein 1-A

    See identical proteins and their annotated locations for NP_001084072.1

    Status: PROVISIONAL

    Source sequence(s)
    U14169
    UniProtKB/Swiss-Prot
    B7ZRW6, B7ZRZ4, Q91572
    Related
    ENSXLAP00005108790.1, ENSXLAT00005110954.1
    Conserved Domains (4) summary
    cd12723
    Location:311 → 418
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:429 → 514
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:506 → 561
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1 → 309
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    100129026..100171794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041585019.1 → XP_041440953.1  cytoplasmic polyadenylation element-binding protein 1-A isoform X3

    UniProtKB/TrEMBL
    A0A8J1MHF3, A0A974DC99
    Conserved Domains (2) summary
    smart00360
    Location:314 → 376
    RRM; RNA recognition motif
    cd19757
    Location:511 → 551
    Bbox1; B-box-type 1 zinc finger (Bbox1)

  2. XM_041585018.1 → XP_041440952.1  cytoplasmic polyadenylation element-binding protein 1-A isoform X2

    UniProtKB/TrEMBL
    A0A8J1MGW1, A0A974DC99
    Conserved Domains (2) summary
    smart00360
    Location:329 → 391
    RRM; RNA recognition motif
    cd19757
    Location:526 → 566
    Bbox1; B-box-type 1 zinc finger (Bbox1)

  3. XM_041585017.1 → XP_041440951.1  cytoplasmic polyadenylation element-binding protein 1-A isoform X1

    UniProtKB/TrEMBL
    A0A8J1MHU0, A0A974DC99
    Related
    ENSXLAP00005108787.1, ENSXLAT00005110951.1
    Conserved Domains (2) summary
    smart00360
    Location:329 → 396
    RRM; RNA recognition motif
    cd19757
    Location:531 → 571
    Bbox1; B-box-type 1 zinc finger (Bbox1)

  4. XM_041585020.1 → XP_041440954.1  cytoplasmic polyadenylation element-binding protein 1-A isoform X4

    UniProtKB/TrEMBL
    A0A8J1MIS3, A0A974DC99
    Conserved Domains (2) summary
    smart00360
    Location:275 → 342
    RRM; RNA recognition motif
    cd19757
    Location:477 → 517
    Bbox1; B-box-type 1 zinc finger (Bbox1)

  5. XM_041585021.1 → XP_041440955.1  cytoplasmic polyadenylation element-binding protein 1-A isoform X4

    UniProtKB/TrEMBL
    A0A8J1MIS3, A0A974DC99
    Related
    ENSXLAP00005108785.1, ENSXLAT00005110949.1
    Conserved Domains (2) summary
    smart00360
    Location:275 → 342
    RRM; RNA recognition motif
    cd19757
    Location:477 → 517
    Bbox1; B-box-type 1 zinc finger (Bbox1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91572.2 GenPept UniProtKB/Swiss-Prot:Q91572

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