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Rbp6 RNA-binding protein 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39919, updated on 2-Nov-2024

Summary

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Official Symbol
Rbp6provided by FlyBase
Official Full Name
RNA-binding protein 6provided by FlyBase
Primary source
FLYBASE:FBgn0260943
Locus tag
Dmel_CG32169
See related
AllianceGenome:FB:FBgn0260943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE25373; CG14055; CG14056; CG32169; CG6573; Dmel\CG32169; rbp6; rrm6; RRM6
Summary
Predicted to enable mRNA binding activity and poly(U) RNA binding activity. Predicted to be involved in regulation of translation and stem cell development. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; female germline cell; ganglia; and neurohemal organ. Orthologous to several human genes including MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Rbp6 in Genome Data Viewer
Location:
73E5-74A1; 3-45 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17058774..17238212, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17051874..17231312, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene rogdi Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43433 Neighboring gene AFG3 like matrix AAA peptidase subunit 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency. Eiman MN, et al. Sci Rep, 2024 Jan 2. PMID 38168575, Free PMC Article
  2. RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family. Sutherland JM, et al. Asian J Androl, 2015 Jul-Aug. PMID 25851660, Free PMC Article
  3. Drosophila Rbp6 is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour. Siddall NA, et al. PLoS One, 2012. PMID 23209605, Free PMC Article
  4. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Markmiller S, et al. Cell, 2018 Jan 25. PMID 29373831, Free PMC Article
  5. α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach. Mitchell CL, et al. PLoS One, 2017. PMID 28241077, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables single-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RNA-binding protein 6
Names
CG32169-PA
CG32169-PB
CG32169-PC
CG32169-PD
CG32169-PE
CG32169-PF
CG32169-PG
Rbp6-PA
Rbp6-PB
Rbp6-PC
Rbp6-PD
Rbp6-PE
Rbp6-PF
Rbp6-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17058774..17238212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275050.2 → NP_001261979.1  RNA-binding protein 6, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCV2
    Conserved Domains (2) summary
    cd12323
    Location:119 → 192
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:30 → 105
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  2. NM_001259883.2 → NP_001246812.1  RNA-binding protein 6, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246812.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NG33
    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 159
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  3. NM_001104162.4 → NP_001097632.1  RNA-binding protein 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097632.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVE5
    Conserved Domains (2) summary
    COG0724
    Location:5 → 84
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  4. NM_001259884.2 → NP_001246813.1  RNA-binding protein 6, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246813.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDB5
    Conserved Domains (2) summary
    COG0724
    Location:5 → 84
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  5. NM_168718.3 → NP_730245.2  RNA-binding protein 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730245.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JNU7, A8JNU8, Q26276, Q8MQZ1, Q9VVE5
    Conserved Domains (2) summary
    cd12323
    Location:119 → 192
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:30 → 105
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  6. NM_001144489.3 → NP_001137961.1  RNA-binding protein 6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z063
    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 162
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  7. NM_001104161.3 → NP_001097631.1  RNA-binding protein 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVE5
    Conserved Domains (2) summary
    cd12323
    Location:119 → 192
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:31 → 105
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z063 B7Z063
M9NDB5 M9NDB5
M9NG33 M9NG33
M9PCV2 M9PCV2
Q9VVE5.3 Q9VVE5

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