grem1.L gremlin 1, DAN family BMP antagonist L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: grem1.L
Official Full Name: gremlin 1, DAN family BMP antagonist L homeolog
Primary source: Xenbase:XB-GENE-865098
Locus tag: XELAEV_18039980mg
See related: EnsemblRapid:ENSXLAG00005018770 AllianceGenome:Xenbase:XB-GENE-865098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: grem1; cktsf1b1
Summary: Enables BMP binding activity; heparan sulfate proteoglycan binding activity; and morphogen activity. Involved in neural crest cell delamination. Acts upstream of or within several processes, including mesenchymal cell differentiation; regionalization; and sequestering of BMP in extracellular matrix. Located in extracellular space. Is expressed in anatomical system; ectoderm; mesenchyme; and pharyngeal arch. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (102903451..102918109, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (88217870..88232584, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning
Title: Gremlin1 induces anterior-posterior limb bifurcations in developing Xenopus limbs but does not enhance limb regeneration.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP binding	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables heparan sulfate proteoglycan binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables morphogen activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell delamination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within neural crest formation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pronephric duct development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sequestering of BMP from receptor via BMP binding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sequestering of BMP in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within somite rostral/caudal axis specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gremlin-1

Names: cysteine knot superfamily 1, BMP antagonist 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090277.1 → NP_001083746.1 gremlin-1 precursor

See identical proteins and their annotated locations for NP_001083746.1

Status: PROVISIONAL

Source sequence(s)

AF045798

UniProtKB/Swiss-Prot

O73754

UniProtKB/TrEMBL

A0A974C8W7, B7ZQZ5

Related

ENSXLAP00005055443.1, ENSXLAT00005056648.1

Conserved Domains (1) summary

pfam03045
Location:74 → 177

DAN; DAN domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

102903451..102918109 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)