foxj1.S forkhead box J1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: foxj1.S
Official Full Name: forkhead box J1 S homeolog
Primary source: Xenbase:XB-GENE-6254646
Locus tag: XELAEV_18046720mg
See related: EnsemblRapid:ENSXLAG00005017077 AllianceGenome:Xenbase:XB-GENE-6254646
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hfh4; foxJ1; hfh-4; foxj1a; foxj1-a; foxj1-b; foxj1.1; xfoxj1'
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within cilium assembly. Predicted to be located in nucleus. Is expressed in anatomical system and primary germ layer. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (40621017..40626244, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (33985031..33990258, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the cilia that underlie left-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are severely shortened or fail to form in Foxj1 morphants.
Title: The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos.
Report of the complete amino acid sequence and developmental expression pattern of Xenopus FoxJ1.
Title: Isolation and developmental expression of Xenopus FoxJ1 and FoxK1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: forkhead box protein J1-A

Names: forkhead protein 5; xFKH5; xFoxJ1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090177.1 → NP_001083646.1 forkhead box protein J1-A

See identical proteins and their annotated locations for NP_001083646.1

Status: PROVISIONAL

Source sequence(s)

AJ609390

UniProtKB/Swiss-Prot

Q6DCY6, Q708W2, Q9PS84

UniProtKB/TrEMBL

A0A974BTF6, A0A974BY45

Related

ENSXLAP00005050356.1, ENSXLAT00005051497.1

Conserved Domains (1) summary

pfam00250
Location:124 → 210

Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

40621017..40626244 complement

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GenBank, FASTA, Sequence Viewer (Graphics)