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has3.S hyaluronan synthase 3 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399037, updated on 4-Nov-2024

Summary

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Official Symbol
has3.S
Official Full Name
hyaluronan synthase 3 S homeolog
Primary source
Xenbase:XB-GENE-987831
Locus tag
XELAEV_18024917mg
See related
EnsemblRapid:ENSXLAG00005010040 AllianceGenome:Xenbase:XB-GENE-987831
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
has3; xhas3
Summary
Predicted to enable hyaluronan synthase activity. Predicted to act upstream of or within extracellular matrix assembly and extracellular polysaccharide biosynthetic process. Predicted to be located in Golgi membrane; cytoplasmic vesicle; and plasma membrane. Is expressed in ectoderm; urinary system; and vestibuloauditory system. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See has3.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
5
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (43174892..43187431, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (41764131..41819237, complement)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene beta-2-syntrophin Neighboring gene chromosome transmission fidelity protein 8 homolog Neighboring gene UTP4 small subunit processome component S homeolog Neighboring gene cadherin 1, type 1 S homeolog Neighboring gene cadherin 3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning, genomic organization and developmental expression of the Xenopus laevis hyaluronan synthase 3. Vigetti D, et al. Matrix Biol, 2003 Nov. PMID 14667843
  2. Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis. Fujimoto K, et al. Dev Genes Evol, 2018 Dec. PMID 30430240

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest that hyaluronan newly synthesized by HAS2 and/or HAS3 is required for intestinal stem cell development through a positive feedback loop and is involved in the formation of the stem cell niche during metamorphosis.
    Title: Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis.
  2. sequence of xlHAS3(hyaluronan synthase 3) mRNA, its genomic organization and expression in adult tissues as well as during embryonic development; in situ hybridization indicates that expression is restricted to the developing inner ear and cement gland
    Title: Molecular cloning, genomic organization and developmental expression of the Xenopus laevis hyaluronan synthase 3.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronan synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronan synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within extracellular polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular polysaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within hyaluronan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hyaluronan synthase 3
Names
HA synthase 3
Hyaluronate synthase 3
hyaluronic acid synthase 3
XP_018114998.2
XP_041417114.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    43174892..43187431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041561180.1 → XP_041417114.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    O57426, Q6W9J2
    UniProtKB/TrEMBL
    A0A1L8GEV1, A0A974D0W2
    Conserved Domains (1) summary
    cd06434
    Location:91 → 363
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

  2. XM_018259509.2 → XP_018114998.2  hyaluronan synthase 3 isoform X2

    UniProtKB/Swiss-Prot
    O57426, Q6W9J2
    UniProtKB/TrEMBL
    A0A8J0UZN2
    Related
    ENSXLAP00005029546.1, ENSXLAT00005030292.1
    Conserved Domains (1) summary
    cd06434
    Location:82 → 354
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001090173.1: Suppressed sequence

    Description
    NM_001090173.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O57426.2 GenPept UniProtKB/Swiss-Prot:O57426

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