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esr1.L estrogen receptor 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398734, updated on 4-Nov-2024

Summary

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Official Symbol
esr1.L
Official Full Name
estrogen receptor 1 L homeolog
Primary source
Xenbase:XB-GENE-864840
Locus tag
XELAEV_18026742mg
See related
EnsemblRapid:ENSXLAG00005016266 AllianceGenome:Xenbase:XB-GENE-864840
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ER; XER; esr; esr1; esr1a; nr3a1; xesr1; ERbeta; esr1-a; esr1-b; xesr-1; ERalpha; ER-alpha; xlERalpha1; xlERalpha2
Summary
Predicted to enable several functions, including estrogen response element binding activity; nuclear estrogen receptor activity; and zinc ion binding activity. Acts upstream of or within left/right axis specification. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See esr1.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (49625129..49743175, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (48455744..48573461, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene MYC target 1 L homeolog Neighboring gene spectrin repeat containing, nuclear envelope 1 L homeolog Neighboring gene coiled-coil domain containing 170 L homeolog Neighboring gene zinc finger and BTB domain containing 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An estrogen receptor mutant exhibiting hormone-independent transactivation and enhanced affinity for the estrogen response element. Xing H, et al. J Biol Chem, 1993 Nov 5. PMID 8226845
  2. The Xenopus laevis estrogen receptor: sequence homology with human and avian receptors and identification of multiple estrogen receptor messenger ribonucleic acids. Weiler IJ, et al. Mol Endocrinol, 1987 May. PMID 3274894
  3. Antagonistic role of XESR1 and XESR5 in mesoderm formation in Xenopus laevis. Kinoshita T, et al. Int J Dev Biol, 2011. PMID 21425079
  4. A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome. Tanaka K, et al. Dev Biol, 2014 Mar 1. PMID 24440151, Free PMC Article
  5. Estrogen receptor expression in laryngeal muscle in relation to estrogen-dependent increases in synapse strength. Wu KH, et al. Neuroendocrinology, 2003 Aug. PMID 12915759

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables estrogen response element binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within left/right axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
estrogen receptor
Names
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
estrogen receptor 1 a
estrogen receptor alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089617.1 → NP_001083086.1  estrogen receptor

    See identical proteins and their annotated locations for NP_001083086.1

    Status: PROVISIONAL

    Source sequence(s)
    AY310904
    UniProtKB/Swiss-Prot
    P81559
    UniProtKB/TrEMBL
    A0A974CUB0, Q6W5G7
    Conserved Domains (4) summary
    cd06949
    Location:301 → 538
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:174 → 255
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 175
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:547 → 585
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    49625129..49743175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041562111.1 → XP_041418045.1  estrogen receptor isoform X1

    UniProtKB/Swiss-Prot
    P81559
    UniProtKB/TrEMBL
    A0A974CUB0, Q6W5G7
    Related
    ENSXLAP00005047880.1, ENSXLAT00005048995.1
    Conserved Domains (4) summary
    cd06949
    Location:301 → 538
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:174 → 255
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 175
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:547 → 585
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81559.1 GenPept UniProtKB/Swiss-Prot:P81559

Gene LinkOut

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