birc5.L baculoviral IAP repeat-containing 5 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: birc5.L
Official Full Name: baculoviral IAP repeat-containing 5 L homeolog
Primary source: Xenbase:XB-GENE-5851077
Locus tag: XELAEV_18013534mg
See related: EnsemblRapid:ENSXLAG00005005411 AllianceGenome:Xenbase:XB-GENE-5851077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Su2; BIR1; api4; svv1; XBIR1; epr-1; xsurv; birc5.1; birc5.1-a; birc5.1-b; birc5.1.L; birc5.1.S; xSurvivin1
Summary: Predicted to enable small GTPase binding activity. Predicted to act upstream of or within several processes, including negative regulation of DNA-templated transcription; protein phosphorylation; and spindle assembly. Predicted to be located in kinetochore; midbody; and nucleus. Predicted to be part of chromosome passenger complex. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (152262018..152264242)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (146391418..146393285)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
part_of chromosome passenger complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 5.1-B

Names: baculoviral IAP repeat-containing 5, gene 1 L homeolog; baculoviral IAP repeat-containing 5, gene 1 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.