nfatc3.S nuclear factor of activated T cells 3 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nfatc3.S
Official Full Name: nuclear factor of activated T cells 3 S homeolog
Primary source: Xenbase:XB-GENE-866300
Locus tag: XELAEV_18024685mg
See related: EnsemblRapid:ENSXLAG00005004621 AllianceGenome:Xenbase:XB-GENE-866300
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nf-at; nfat4; nfatx; nfatc3
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within calcineurin-NFAT signaling cascade and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Is expressed in ectoderm; musculoskeletal system; nervous system; vestibuloauditory system; and visual system. Orthologous to human NFATC3 (nuclear factor of activated T cells 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 4S

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (24330707..24391352)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (23663639..23724737)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

transcriptional control of morphological and electrophysiological properties of neurons is mediated by distinct NFAT interactions
Title: Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling.
NF-AT affects neural convergent extension.
Title: XNF-ATc3 affects neural convergent extension.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear factor of activated T cells 3 S homeolog

Names: nuclear factor of activated T-cell; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088748.1 → NP_001082217.1 nuclear factor of activated T cells 3 S homeolog

See identical proteins and their annotated locations for NP_001082217.1

Status: PROVISIONAL

Source sequence(s)

AB037471

UniProtKB/TrEMBL

A0A974HLK6, B7ZQA4, Q8QHM1

Related

ENSXLAP00005013862.1, ENSXLAT00005014044.1

Conserved Domains (2) summary

cd01178
Location:575 → 675

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cl08275
Location:397 → 570

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)