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bcl2l1.S BCL2 like 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398251, updated on 4-Nov-2024

Summary

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Official Symbol
bcl2l1.S
Official Full Name
BCL2 like 1 S homeolog
Primary source
Xenbase:XB-GENE-6251803
Locus tag
XELAEV_18046383mg
See related
EnsemblRapid:ENSXLAG00005030008 AllianceGenome:Xenbase:XB-GENE-6251803
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
xR11; bclxl; bcl-XL; bcl2l1; bcl-x(l)
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to act upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bcl2l1.S in Genome Data Viewer
Location:
chromosome: 9_10S
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (18170412..18176737, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (17451794..17458161, complement)

Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene ABC-type organic anion transporter ABCA8 Neighboring gene uncharacterized LOC121398834 Neighboring gene uncharacterized LOC121398835 Neighboring gene cytochrome c oxidase subunit 4I2 S homeolog Neighboring gene TPX2, microtubule-associated S homeolog Neighboring gene uncharacterized LOC108702688 Neighboring gene uncharacterized LOC121398825

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The roles of Bcl-xL in modulating apoptosis during development of Xenopus laevis. Johnston J, et al. BMC Dev Biol, 2005 Sep 26. PMID 16185362, Free PMC Article
  2. Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis. Nakajima K, et al. Dev Dyn, 2003 Jun. PMID 12761852
  3. Cloning, characterization and expression of two Xenopus bcl-2-like cell-survival genes. Cruz-Reyes J, et al. Gene, 1995 Jun 9. PMID 7607538
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC131371

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apoptosis regulator R11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    18170412..18176737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018237338.2 → XP_018092827.1  apoptosis regulator R11

    UniProtKB/TrEMBL
    A0A974H0V0, Q2TAP5, Q90ZH2

  2. XM_018237337.2 → XP_018092826.1  apoptosis regulator R11

    UniProtKB/TrEMBL
    A0A974H0V0, Q2TAP5, Q90ZH2
    Related
    ENSXLAP00005089692.1, ENSXLAT00005091367.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001088678.1: Suppressed sequence

    Description
    NM_001088678.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91828.1 GenPept UniProtKB/Swiss-Prot:Q91828

Gene LinkOut

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Molecular Biology Databases
Research Materials