pacsin2.S protein kinase C and casein kinase substrate in neurons 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pacsin2.S
Official Full Name: protein kinase C and casein kinase substrate in neurons 2 S homeolog
Primary source: Xenbase:XB-GENE-489582
Locus tag: XELAEV_18019736mg
See related: EnsemblRapid:ENSXLAG00005001038 AllianceGenome:Xenbase:XB-GENE-489582
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sdpii; pacsin2
Summary: Predicted to enable phosphatidic acid binding activity. Predicted to act upstream of or within several processes, including endocytosis; plasma membrane organization; and regulation of endocytosis. Predicted to be located in several cellular components, including caveola; endosome; and ruffle membrane. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (1657037..1683373, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (1655439..1681062, complement)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that PACSIN2 is involved in the regulation of gastrulation, possibly through regulating cell adhesion.
Title: PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within caveola assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within plasma membrane tubulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein kinase C and casein kinase substrate in neurons protein 2

Names: x-PACSIN2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088481.1 → NP_001081950.1 protein kinase C and casein kinase substrate in neurons protein 2

See identical proteins and their annotated locations for NP_001081950.1

Status: PROVISIONAL

Source sequence(s)

BC071076

UniProtKB/Swiss-Prot

Q6GR55, Q9DDA9

UniProtKB/TrEMBL

A0A974HPU3

Related

ENSXLAP00005003126.1, ENSXLAT00005003188.1

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:420 → 475

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

1657037..1683373 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041587525.1 → XP_041443459.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X3

UniProtKB/TrEMBL

A0A8J1MNU3, A0A974HPU3

Related

ENSXLAP00005003128.1, ENSXLAT00005003190.1

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:387 → 442

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_041587524.1 → XP_041443458.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X2

UniProtKB/TrEMBL

A0A8J1MPX8, A0A974HPU3

Related

ENSXLAP00005003131.1, ENSXLAT00005003193.1

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:389 → 444

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_041587522.1 → XP_041443456.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

UniProtKB/TrEMBL

A0A8J1MNZ1, A0A974HPU3

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:422 → 477

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_041587523.1 → XP_041443457.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

UniProtKB/TrEMBL

A0A8J1MNZ1, A0A974HPU3

Related

ENSXLAP00005003127.1, ENSXLAT00005003189.1

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:422 → 477

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2