orc1.L origin recognition complex subunit 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: orc1.L
Official Full Name: origin recognition complex subunit 1 L homeolog
Primary source: Xenbase:XB-GENE-998003
Locus tag: XELAEV_18023178mg
See related: EnsemblRapid:ENSXLAG00005035784 AllianceGenome:Xenbase:XB-GENE-998003
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: orc1; orc1l; xorc1
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and DNA replication origin binding activity. Predicted to act upstream of or within DNA replication initiation and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 4L

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (91878238..91911286, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (86577101..86610197, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of nuclear origin of replication recognition complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: origin recognition complex subunit 1 L homeolog

Names: origin recognition complex protein 1; origin recognition complex, subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088337.1 → NP_001081806.1 origin recognition complex subunit 1 L homeolog

See identical proteins and their annotated locations for NP_001081806.1

Status: PROVISIONAL

Source sequence(s)

U67190

UniProtKB/TrEMBL

P70049, Q5BL88

Related

ENSXLAP00005107029.1, ENSXLAT00005109141.1

Conserved Domains (5) summary

cd08768
Location:796 → 879

Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding

smart00382
Location:552 → 702

AAA; ATPases associated with a variety of cellular activities

cd04719
Location:44 → 169

BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...

pfam00004
Location:556 → 701

AAA; ATPase family associated with various cellular activities (AAA)

pfam13191
Location:530 → 580

AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

91878238..91911286 complement

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GenBank, FASTA, Sequence Viewer (Graphics)