tpr.S translocated promoter region, nuclear basket protein S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tpr.S
Official Full Name: translocated promoter region, nuclear basket protein S homeolog
Primary source: Xenbase:XB-GENE-6252143
Locus tag: XELAEV_18025631mg
See related: EnsemblRapid:ENSXLAG00005007714 AllianceGenome:Xenbase:XB-GENE-6252143
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: tpr; XTPR; tpr.L
Summary: Predicted to enable several functions, including heat shock protein binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Predicted to act upstream of or within several processes, including RNA transport; regulation of nucleocytoplasmic transport; and regulation of organelle organization. Located in nuclear membrane and nuclear periphery. Part of nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (98705853..98809067)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (92367093..92471117)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables heat shock protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables protein-membrane adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within RNA import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA export from nucleus in response to heat stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within nuclear matrix organization	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within nuclear pore complex assembly	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within nuclear pore organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein import into nucleus	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitotic sister chromatid separation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to epidermal growth factor	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
NOT located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear inclusion body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoprotein TPR

Names: NPC-associated intranuclear protein; Nucleoprotein TPR; Translocated promoter region and nuclear basket protein; translocated promoter region, nuclear basket protein L homeolog