bmpr2.S bone morphogenetic protein receptor type II S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: bmpr2.S
Official Full Name: bone morphogenetic protein receptor type II S homeolog
Primary source: Xenbase:XB-GENE-865330
Locus tag: XELAEV_180473591mg
See related: EnsemblRapid:ENSXLAG00005028309 AllianceGenome:Xenbase:XB-GENE-865330
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bmr2; pph1; bmpr2; bmpr3; brk-3; t-alk; bmprii; bmpr-ii; xbmpr-ii
Summary: Predicted to enable ATP binding activity and transforming growth factor beta receptor activity. Predicted to act upstream of or within BMP signaling pathway; blood vessel development; and protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Is expressed in cardiovascular system; mesenchyme; nervous system; and primary germ layer. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease 1. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 9_10S

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (78610360..78696814, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (71902350..71987221, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jiraiya selectively forms a complex with type II BMP receptor (BMPRII) and downregulates the cell surface localization of functional BMPRII.
Title: Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: bone morphogenetic protein receptor type II S homeolog

Names: BMP type II receptor; bone morphogenetic protein receptor, type 2 (serine/threonine kinase)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088190.1 → NP_001081659.1 bone morphogenetic protein receptor type II S homeolog

See identical proteins and their annotated locations for NP_001081659.1

Status: PROVISIONAL

Source sequence(s)

U81958

UniProtKB/TrEMBL

B7ZRI0, P79954

Related

ENSXLAP00005084236.1, ENSXLAT00005085885.1

Conserved Domains (3) summary

smart00220
Location:228 → 519

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:231 → 528

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:80 → 152

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

78610360..78696814 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041577685.1 → XP_041433619.1 bone morphogenetic protein receptor type II S homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1LW73, B7ZRI0

Conserved Domains (1) summary

cd14054
Location:59 → 356

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors