polb.S polymerase (DNA directed), beta S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: polb.S
Official Full Name: polymerase (DNA directed), beta S homeolog
Primary source: Xenbase:XB-GENE-999702
Locus tag: XELAEV_18020165mg
See related: EnsemblRapid:ENSXLAG00005018242 AllianceGenome:Xenbase:XB-GENE-999702
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: polb
Summary: Predicted to enable DNA binding activity; catalytic activity, acting on DNA; and metal ion binding activity. Predicted to act upstream of or within base-excision repair. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (22242488..22261477)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (21858834..21876902)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA polymerase beta

Names: 5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase

NP_001081643.1

EC 2.7.7.7

EC 4.2.99.18

XP_018109615.1

EC 2.7.7.7

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088174.1 → NP_001081643.1 DNA polymerase beta

See identical proteins and their annotated locations for NP_001081643.1

Status: PROVISIONAL

Source sequence(s)

BC106329

UniProtKB/Swiss-Prot

O57383, Q3KQ91

UniProtKB/TrEMBL

A0A974D936

Related

ENSXLAP00005053835.1, ENSXLAT00005055009.1

Conserved Domains (2) summary

cd00141
Location:13 → 332

NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

smart00483
Location:12 → 333

POLXc; DNA polymerase X family