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grin1.L glutamate ionotropic receptor NMDA type subunit 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397953, updated on 4-Nov-2024

Summary

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Official Symbol
grin1.L
Official Full Name
glutamate ionotropic receptor NMDA type subunit 1 L homeolog
Primary source
Xenbase:XB-GENE-866327
Locus tag
XELAEV_18038140mg
See related
EnsemblRapid:ENSXLAG00005024018 AllianceGenome:Xenbase:XB-GENE-866327
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
NR1; GluN1; grin1; nmda1; NMD-R1; nmdar1
Summary
Enables NMDA glutamate receptor activity. Acts upstream of or within calcium ion transmembrane transport and response to zinc ion. Located in plasma membrane. Part of NMDA selective glutamate receptor complex. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See grin1.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
20
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (990061..1014724, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (834233..858896, complement)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 2 L homeolog Neighboring gene uncharacterized LOC108698102 Neighboring gene uncharacterized XB5992703 L homeolog Neighboring gene zinc finger protein 618 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits. Soloviev MM, et al. J Biol Chem, 1996 Dec 20. PMID 8955083
  2. [A new type of ionotropic glutamate receptors]. Solov'ev MM, et al. Bioorg Khim, 1996 Jun. PMID 8975675
  3. Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain. Romero-Hernandez A, et al. Neuron, 2016 Dec 21. PMID 27916457, Free PMC Article
  4. An NMDA receptor-dependent mechanism for subcellular segregation of sensory inputs in the tadpole optic tectum. Hamodi AS, et al. Elife, 2016 Nov 23. PMID 27879199, Free PMC Article
  5. Revisiting the postulated "unitary glutamate receptor": electrophysiological and pharmacological analysis in two heterologous expression systems fails to detect evidence for its existence. Schmidt C, et al. Mol Pharmacol, 2006 Jan. PMID 16214956

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cross-Talk between P2X and NMDA Receptors.
    Title: Cross-Talk between P2X and NMDA Receptors.
  2. Xray crystal structure and mechanism of NMDA receptor channel block by MK-801 and memantine
    Title: Mechanism of NMDA receptor channel block by MK-801 and memantine.
  3. An NMDA receptor-dependent mechanism for subcellular segregation of sensory inputs in the tadpole optic tectum has been reported.
    Title: An NMDA receptor-dependent mechanism for subcellular segregation of sensory inputs in the tadpole optic tectum.
  4. analysis of conformational changes at the agonist binding domain of the N-methyl-D-aspartic acid receptor
    Title: Conformational changes at the agonist binding domain of the N-methyl-D-aspartic acid receptor.
  5. Establishment of late-phase long-term potentiation (L-LTP) in vivo requires NMDAR activation in the postsynaptic tectal cells within a critical time window after LTP induction.
    Title: Postinduction requirement of NMDA receptor activation for late-phase long-term potentiation of developing retinotectal synapses in vivo.
  6. PIP2 supports the open state of NMDA receptors via the adaptor protein alpha-actinin. PIP2 and alpha-actinin act like a two-component hinge keeping the channel gate in its open state.
    Title: Phosphatidylinositol-4,5-bisphosphate and alpha-actinin: two-component hinge for the NMDA receptor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables NMDA glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NMDA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-gated calcium ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to zinc ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NMDA selective glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate receptor ionotropic, NMDA 1
Names
N-methyl-D-aspartate receptor subunit NR1
NMDA glutamate receptor
NMDA receptor
glutamate receptor, ionotropic, N-methyl D-aspartate 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088146.1 → NP_001081615.1  glutamate receptor ionotropic, NMDA 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001081615.1

    Status: PROVISIONAL

    Source sequence(s)
    X94156
    UniProtKB/Swiss-Prot
    A0A1L8F5J9, C0KD15, C0KD16, C0KD17, C0KD18, C0KD19, Q4PLR7, Q91805, Q91977
    Related
    ENSXLAP00005071467.1, ENSXLAT00005073014.1
    Conserved Domains (5) summary
    cd06379
    Location:18 → 404
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:416 → 818
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:580 → 843
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39 → 378
    ANF_receptor; Receptor family ligand binding region
    pfam10562
    Location:854 → 882
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

  2. NM_001088147.1 → NP_001081616.1  glutamate receptor ionotropic, NMDA 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001081616.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ066918
    UniProtKB/Swiss-Prot
    A0A1L8F5J9, C0KD15, C0KD16, C0KD17, C0KD18, C0KD19, Q4PLR7, Q91805, Q91977
    Related
    ENSXLAP00005071244.1, ENSXLAT00005072791.1
    Conserved Domains (5) summary
    cd06379
    Location:18 → 383
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    cd13719
    Location:395 → 797
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:559 → 822
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39 → 357
    ANF_receptor; Receptor family ligand binding region
    pfam10562
    Location:833 → 861
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    990061..1014724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1L8F5J9.1 GenPept UniProtKB/Swiss-Prot:A0A1L8F5J9

Gene LinkOut

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Molecular Biology Databases
Research Materials