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nasp.S nuclear autoantigenic sperm protein (histone-binding) S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397901, updated on 4-Nov-2024

Summary

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Official Symbol
nasp.S
Official Full Name
nuclear autoantigenic sperm protein (histone-binding) S homeolog
Primary source
Xenbase:XB-GENE-980259
Locus tag
XELAEV_18025187mg
See related
EnsemblRapid:ENSXLAG00005012188 AllianceGenome:Xenbase:XB-GENE-980259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nasp; n1/n2
Summary
Enables importin-alpha family protein binding activity. Predicted to act upstream of or within CENP-A containing chromatin assembly and DNA replication-dependent chromatin assembly. Predicted to be located in nucleoplasm. Is expressed in ectoderm; musculoskeletal system; nervous system; pharyngeal arch; and visual system. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nasp.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (70595316..70607075, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (64363795..64375523, complement)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene palmitoyltransferase ZDHHC15B-like Neighboring gene GC-rich promoter binding protein 1-like 1 S homeolog Neighboring gene aldo-keto reductase family 1, member A1 (aldehyde reductase) S homeolog Neighboring gene peroxiredoxin 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis. Kleinschmidt JA, et al. EMBO J, 1986 Dec 20. PMID 3549279, Free PMC Article
  2. Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha. Fontes MR, et al. J Biol Chem, 2003 Jul 25. PMID 12695505
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables importin-alpha family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within CENP-A containing chromatin assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication-dependent chromatin assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone-binding protein N1/N2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088068.1 → NP_001081537.1  histone-binding protein N1/N2

    See identical proteins and their annotated locations for NP_001081537.1

    Status: PROVISIONAL

    Source sequence(s)
    X04712
    UniProtKB/Swiss-Prot
    P06180
    UniProtKB/TrEMBL
    A0A974D1H3
    Related
    ENSXLAP00005035703.1, ENSXLAT00005036596.1
    Conserved Domains (4) summary
    sd00006
    Location:356 → 386
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:399 → 426
    TPR_1; Tetratricopeptide repeat
    pfam10516
    Location:357 → 394
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:356 → 431
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    70595316..70607075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018259457.2 → XP_018114946.1  histone-binding protein N1/N2 isoform X1

    UniProtKB/TrEMBL
    A0A1L8GFM0, A0A974D090, Q6DDS8
    Related
    ENSXLAP00005035713.1, ENSXLAT00005036607.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06180.3 GenPept UniProtKB/Swiss-Prot:P06180

Gene LinkOut

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