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fgb.L fibrinogen beta chain L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397825, updated on 4-Nov-2024

Summary

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Official Symbol
fgb.L
Official Full Name
fibrinogen beta chain L homeolog
Primary source
Xenbase:XB-GENE-864955
Locus tag
XELAEV_18005467mg
See related
EnsemblRapid:ENSXLAG00005029529 AllianceGenome:Xenbase:XB-GENE-864955
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fgb
Summary
Predicted to enable signaling receptor binding activity. Predicted to act upstream of or within platelet activation and protein polymerization. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fgb.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (57872583..57881740, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (47562568..47571757, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene fibrinogen gamma chain L homeolog Neighboring gene fibrinogen alpha chain L homeolog Neighboring gene pleiotropic regulator 1 L homeolog Neighboring gene dachsous cadherin-related 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA and amino-acid sequences and organization of the gene encoding the B beta subunit of fibrinogen from Xenopus laevis. Roberts LR, et al. Gene, 1995 Jul 28. PMID 7642099
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC85418

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within platelet activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of fibrinogen complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibrinogen beta chain
Names
B fibrinopeptide
fibrinogen B-beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087949.1 → NP_001081418.1  fibrinogen beta chain precursor

    See identical proteins and their annotated locations for NP_001081418.1

    Status: PROVISIONAL

    Source sequence(s)
    U19618
    UniProtKB/TrEMBL
    A0A974DWX0, Q91546, Q91589
    Related
    ENSXLAP00005088199.1, ENSXLAT00005089861.1
    Conserved Domains (2) summary
    pfam08702
    Location:92 → 234
    Fib_alpha; Fibrinogen alpha/beta chain family
    cl00085
    Location:237 → 486
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    57872583..57881740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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