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TPM4 tropomyosin 4 [ Sus scrofa (pig) ]

Gene ID: 397608, updated on 17-Aug-2024

Summary

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Official Symbol
TPM4provided by VGNC
Official Full Name
tropomyosin 4provided by VGNC
Primary source
VGNC:VGNC:94339
See related
Ensembl:ENSSSCG00000013849
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in lung (RPKM 213.9), spleen (RPKM 140.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See TPM4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (61453721..61476781, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (61150543..61173575)

Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 32 member A Neighboring gene calcium and integrin binding family member 3 Neighboring gene hematopoietic SH2 domain containing Neighboring gene RAB8A, member RAS oncogene family Neighboring gene olfactory receptor 1361-like Neighboring gene olfactory receptor 10H1-like Neighboring gene olfactory receptor 2Z1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Tropomyosin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis. Abouhamed M, et al. Eur J Cell Biol, 2003 Sep. PMID 14582535
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. upregulation of tropomyosin 4 (TM4) mRNA is a relevant marker of dedifferentiation in vascular smooth muscle cells.
    Title: Tropomyosin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tropomyosin alpha-4 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214335.1 → NP_999500.1  tropomyosin alpha-4 chain

    See identical proteins and their annotated locations for NP_999500.1

    Status: PROVISIONAL

    Source sequence(s)
    AF087679
    UniProtKB/Swiss-Prot
    P67937
    UniProtKB/TrEMBL
    A0A8D0X3B5, D0G7F7
    Related
    ENSSSCP00000014722.2, ENSSSCT00000015127.4
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

    Range
    61453721..61476781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005661198.1 → XP_005661255.1  tropomyosin alpha-4 chain isoform X1

    UniProtKB/TrEMBL
    A0A5S6HGR0, A0A8D0P6L0, A0A8D0X2W6, A0A8D1NUQ4
    Related
    ENSSSCP00000040331.2, ENSSSCT00000038285.2
    Conserved Domains (2) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin
    pfam16526
    Location:13 → 72
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

  2. XM_021081566.1 → XP_020937225.1  tropomyosin alpha-4 chain isoform X2

    Conserved Domains (1) summary
    pfam00261
    Location:1 → 156
    Tropomyosin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P67937.3 GenPept UniProtKB/Swiss-Prot:P67937

Gene LinkOut

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