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EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 [ Sus scrofa (pig) ]

Gene ID: 397588, updated on 17-Aug-2024

Summary

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Official Symbol
EIF2AK2provided by VGNC
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 2provided by VGNC
Primary source
VGNC:VGNC:87607
See related
Ensembl:ENSSSCG00000008496
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
PKR; PRKR
Expression
Ubiquitous expression in spleen (RPKM 17.8), lung (RPKM 14.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See EIF2AK2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (103041029..103096741)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (109641276..109667770)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene CCAAT enhancer binding protein zeta Neighboring gene CEBPZ opposite strand Neighboring gene sulfotransferase family 6B member 1 Neighboring gene G-patch domain containing 11 Neighboring gene HEAT repeat containing 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication. Li C, et al. Virology, 2017 Sep. PMID 28662438, Free PMC Article
  2. The mRNA regulation of porcine double-stranded RNA-activated protein kinase gene. Asano A, et al. J Vet Med Sci, 2004 Dec. PMID 15644602
  3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interferon-induced, double-stranded RNA-activated protein kinase
Names
double stranded RNA-dependent protein kinase
NP_999484.1
XP_020941521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214319.1 → NP_999484.1  interferon-induced, double-stranded RNA-activated protein kinase

    See identical proteins and their annotated locations for NP_999484.1

    Status: PROVISIONAL

    Source sequence(s)
    AB104654
    UniProtKB/TrEMBL
    A0A8D0K761, Q865A4
    Conserved Domains (3) summary
    smart00220
    Location:268 → 520
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00358
    Location:10 → 75
    DSRM; Double-stranded RNA binding motif
    cl21453
    Location:261 → 522
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    103041029..103096741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021085862.1 → XP_020941521.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A287ABT2, A0A8D0K761, A0A8D0SKD0
    Related
    ENSSSCP00000041474.1, ENSSSCT00000050794.2
    Conserved Domains (2) summary
    smart00358
    Location:101 → 166
    DSRM; Double-stranded RNA binding motif
    cl21453
    Location:261 → 522
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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