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CTSK cathepsin K [ Sus scrofa (pig) ]

Gene ID: 397569, updated on 5-Mar-2024

Summary

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Gene symbol
CTSK
Gene description
cathepsin K
See related
Ensembl:ENSSSCG00000052889
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in subcutaneous adipose (RPKM 88.0), lung (RPKM 20.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See CTSK in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (98389459..98404969)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 4 NC_010446.4 (107639430..107653109)

Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene ceramide synthase 2 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1 Neighboring gene aryl hydrocarbon receptor nuclear translocator Neighboring gene cathepsin S Neighboring gene HORMA domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs. Fontanesi L, et al. Mol Biol Rep, 2010 Jan. PMID 19662513
  2. Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. Tepel C, et al. J Cell Sci, 2000 Dec. PMID 11082042
  3. Comparative analysis of protein coding sequences from human, mouse and the domesticated pig. Jørgensen FG, et al. BMC Biol, 2005 Jan 28. PMID 15679890, Free PMC Article
  4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values.
    Title: A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cathepsin K
NP_999467.1
XP_005663523.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214302.1 → NP_999467.1  cathepsin K precursor

    See identical proteins and their annotated locations for NP_999467.1

    Status: PROVISIONAL

    Source sequence(s)
    AF292030
    UniProtKB/Swiss-Prot
    Q9GLE3
    UniProtKB/TrEMBL
    A0A8W4FN34
    Related
    ENSSSCP00000080764.1, ENSSSCT00000099310.1
    Conserved Domains (2) summary
    smart00848
    Location:27 → 86
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:117 → 328
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

    Range
    98389459..98404969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005663466.3 → XP_005663523.1  cathepsin K isoform X1

    See identical proteins and their annotated locations for XP_005663523.1

    UniProtKB/Swiss-Prot
    Q9GLE3
    UniProtKB/TrEMBL
    A0A8W4FN34
    Related
    ENSSSCP00000075775.1, ENSSSCT00000102124.1
    Conserved Domains (2) summary
    smart00848
    Location:27 → 86
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:117 → 328
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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