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CFH complement factor H [ Sus scrofa (pig) ]

Gene ID: 397525, updated on 5-Mar-2024

Summary

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Gene symbol
CFH
Gene description
complement factor H
See related
Ensembl:ENSSSCG00000010893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
HF1
Expression
Biased expression in liver (RPKM 367.3), mixtures (RPKM 141.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See CFH in Genome Data Viewer
Location:
chromosome: Un
Exon count:
28
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) Unplaced Scaffold NW_018085100.1 (2468667..2570975)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 10 NC_010452.3 (24337539..24406888)

NW_018085100.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102164558 Neighboring gene potassium sodium-activated channel subfamily T member 2 Neighboring gene coagulation factor XIII B chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Factor H in porcine seminal plasma protects sperm against complement attack in genital tracts. Sakaue T, et al. J Biol Chem, 2010 Jan 15. PMID 19920146, Free PMC Article
  2. Pig complement regulator factor H: molecular cloning and functional characterization. Hegasy GA, et al. Immunogenetics, 2003 Oct. PMID 14517701
  3. The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: point mutations in the factor H coding sequence block protein secretion. Hegasy GA, et al. Am J Pathol, 2002 Dec. PMID 12466119, Free PMC Article
  4. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
complement factor H
Names
complement regulator factor H
NP_999446.1
XP_020937501.1
XP_020937502.1
XP_020937503.1
XP_020937504.1
XP_020937505.1
XP_020937507.1
XP_020937508.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214281.2 → NP_999446.1  complement factor H precursor

    See identical proteins and their annotated locations for NP_999446.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ278470
    UniProtKB/TrEMBL
    A0A287BD18, A0A8D0N9M2, A0A8D1CAD6, Q8MI72
    Related
    ENSSSCP00000053987.1, ENSSSCT00000056087.2
    Conserved Domains (4) summary
    cd00033
    Location:146 → 206
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:268 → 320
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:11 → 263
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:85 → 141
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NW_018085100.1 Reference Sscrofa11.1 Primary Assembly

    Range
    2468667..2570975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021081843.1 → XP_020937502.1  complement factor H isoform X2

    UniProtKB/TrEMBL
    A0A287BD18
    Conserved Domains (2) summary
    cd00033
    Location:507 → 560
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cl27761
    Location:11 → 263
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  2. XM_021081844.1 → XP_020937503.1  complement factor H isoform X3

    UniProtKB/TrEMBL
    A0A480W8X5, A0A480Y7M9, A0A8D1CAE4, A0A8D1H7K5
    Conserved Domains (2) summary
    cd00033
    Location:507 → 560
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cl27761
    Location:11 → 263
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  3. XM_021081845.1 → XP_020937504.1  complement factor H isoform X4

    UniProtKB/TrEMBL
    A0A480W8X5, A0A8D1CAE4, A0A8D1H7K5
    Conserved Domains (2) summary
    cd00033
    Location:507 → 560
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cl27761
    Location:11 → 263
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  4. XM_021081842.1 → XP_020937501.1  complement factor H isoform X1

    UniProtKB/TrEMBL
    A0A8D1H8Z1, F1S643, K7GLV1
    Related
    ENSSSCP00000028836.2, ENSSSCT00000036286.4
    Conserved Domains (2) summary
    cd00033
    Location:507 → 560
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cl27761
    Location:11 → 263
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  5. XM_021081846.1 → XP_020937505.1  complement factor H isoform X5

    Conserved Domains (1) summary
    cl27761
    Location:11 → 263
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  6. XM_021081849.1 → XP_020937508.1  complement factor H isoform X7

    UniProtKB/TrEMBL
    A0A8D1Z724
    Conserved Domains (1) summary
    cl27761
    Location:84 → 257
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  7. XM_021081848.1 → XP_020937507.1  complement factor H isoform X6

    UniProtKB/TrEMBL
    A0A8D1Z724
    Conserved Domains (1) summary
    cl27761
    Location:81 → 254
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Nucleotide Protein
Heading Accession and Version

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