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CD3E CD3 epsilon subunit of T-cell receptor complex [ Sus scrofa (pig) ]

Gene ID: 397455, updated on 17-Aug-2024

Summary

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Official Symbol
CD3Eprovided by VGNC
Official Full Name
CD3 epsilon subunit of T-cell receptor complexprovided by VGNC
Primary source
VGNC:VGNC:86414
See related
Ensembl:ENSSSCG00000040140
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
CD3
Expression
Biased expression in spleen (RPKM 92.9), lung (RPKM 22.1) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See CD3E in Genome Data Viewer
Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (45619730..45633972)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (50660852..50675098)

Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene junction adhesion molecule like Neighboring gene myelin protein zero like 3 Neighboring gene myelin protein zero like 2 Neighboring gene CD3 delta subunit of T-cell receptor complex Neighboring gene CD3 gamma subunit of T-cell receptor complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Expression and characterization of recombinant soluble porcine CD3 ectodomain molecules: mapping the epitope of an anti-porcine CD3 monoclonal antibody 898H2-6-15. Peraino JS, et al. Cell Immunol, 2012 Mar-Apr. PMID 22672968, Free PMC Article
  2. Porcine CD3 epsilon: its characterization, expression and involvement in activation of porcine T lymphocytes. Kirkham PA, et al. Immunology, 1996 Apr. PMID 8675218, Free PMC Article
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha-beta T cell receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
T-cell surface glycoprotein CD3 epsilon chain
Names
CD3 epsilon subunit
CD3e molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214227.1 → NP_999392.1  T-cell surface glycoprotein CD3 epsilon chain precursor

    See identical proteins and their annotated locations for NP_999392.1

    Status: PROVISIONAL

    Source sequence(s)
    AY323829
    UniProtKB/Swiss-Prot
    Q7YRN2
    UniProtKB/TrEMBL
    A0A287B968
    Related
    ENSSSCP00000053066.3, ENSSSCT00000056825.3
    Conserved Domains (3) summary
    smart00077
    Location:174 → 194
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:42 → 93
    IG_like; Immunoglobulin like
    pfam16681
    Location:36 → 110
    Ig_5; Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

    Range
    45619730..45633972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YRN2.1 GenPept UniProtKB/Swiss-Prot:Q7YRN2

Gene LinkOut

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