CD59 CD59 molecule [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CD59provided by VGNC
Official Full Name: CD59 moleculeprovided by VGNC
Primary source: VGNC:VGNC:99615
See related: Ensembl:ENSSSCG00000024791
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in ovary (RPKM 99.9), subcutaneous adipose (RPKM 97.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (27186587..27207303)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (29777121..29797735, complement)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59.
Title: Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of alpha-Gal and high production of clusterin and CD59.

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General gene information

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Markers

CD59-3 (e-PCR)
- UniSTS:254035

CD59sts2 (e-PCR)
- UniSTS:258483

CD59 (e-PCR), detects polymorphism
- UniSTS:253940

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables complement binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of activation of membrane attack complex	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CD59 glycoprotein

Names: CD59 molecule (CD59 blood group); MAC-IP; MAC-inhibitory protein; MACIF; membrane attack complex inhibition factor; protectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214170.1 → NP_999335.1 CD59 glycoprotein precursor

See identical proteins and their annotated locations for NP_999335.1

Status: PROVISIONAL

Source sequence(s)

AF020302

UniProtKB/Swiss-Prot

O62680, Q9TR76, Q9XT94

UniProtKB/TrEMBL

A0A8D0P1M7

Related

ENSSSCP00000025898.1, ENSSSCT00000026025.5

Conserved Domains (1) summary

cd00117
Location:26 → 98

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010444.4 Reference Sscrofa11.1 Primary Assembly

Range

27186587..27207303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005661031.3 → XP_005661088.1 CD59 glycoprotein isoform X1

See identical proteins and their annotated locations for XP_005661088.1

UniProtKB/Swiss-Prot

O62680, Q9TR76, Q9XT94

UniProtKB/TrEMBL

A0A8D0P1M7

Conserved Domains (1) summary

cd00117
Location:26 → 98

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...