PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PRKAG3provided by VGNC
Official Full Name: protein kinase AMP-activated non-catalytic subunit gamma 3provided by VGNC
Primary source: VGNC:VGNC:98221
See related: Ensembl:ENSSSCG00000016200
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in longissimus dorsi muscle (RPKM 10.9), heart (RPKM 7.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	15	NC_010457.5 (120859486..120866308, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	15	NC_010457.4 (133800767..133806881)

Chromosome 15 - NC_010457.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings indicate that the genetic basis of muscle residual glycogen in swine can be mainly attributed to two major genes PRKAG3 and PHKG1
Title: Muscle glycogen level and occurrence of acid meat in commercial hybrid pigs are regulated by two low-frequency causal variants with large effects and multiple common variants with small effects.
Activity of glycogen synthase without the allosteric activator glucose 6-phosphate was decreased in gain of function AMPKgamma3(R200Q) relative to all other genotypes
Title: Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation.
Greater net lactate accumulation postmortem (i.e., glycolytic flux) coupled with a lower buffering capacity explains the lower ultimate pH of meat from AMPKgamma3(R200Q) mutant pigs.
Title: Net lactate accumulation and low buffering capacity explain low ultimate pH in the longissimus lumborum of AMPKγ3 R200Q mutant pigs.
allelic frequencies of PRKAG3 in several pig breeds
Title: Allelic frequencies of PRKAG3 in several pig breeds and its technological consequences on a Duroc × Landrace-Large White cross.
The variation in the promoter region of the porcine PRKAG3 gene has associations with meat quality phenotypes, including traits which are influenced by glycolytic potential and muscle metabolism in a breed-dependent manner.
Title: SNP variation in the promoter of the PRKAG3 gene and association with meat quality traits in pig.
PRKAG3 mutation influences muscle characteristics and promotes an oxidative phenotype to a varying degree among muscles with different functions
Title: The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs.
increased rate of glycogen synthesis following exercise in pigs carrying the PRKAG3 mutation correlates with an increased signalling response of Akt and its substrate, AS160.
Title: Effects of exercise on muscle glycogen synthesis signalling and enzyme activities in pigs carrying the PRKAG3 mutation.
the R225Q mutation of PRKAG3 is associated with higher basal AMPK activity and diminished AMP dependence
Title: The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle.
Genetic variation of PRKAG3 was studied in indigenous breeds of China.
Title: Genetic variations of the porcine PRKAG3 gene in Chinese indigenous pig breeds.
findings suggest that the R200Q mutation results in a constitutively active enzyme, leading to hyperaccumulation of glycogen due to the increased influx of glucose
Title: UDP-glucose pyrophosphorylase is upregulated in carriers of the porcine RN- mutation in the AMP-activated protein kinase.

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General gene information

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Markers

MARC_40823-40824:1082135317:1 (e-PCR)
- UniSTS:471569

MARC_40827-40828:1081953873:1 (e-PCR)
- UniSTS:471570

MARC_40829-40830:1081953472:1 (e-PCR)
- UniSTS:471571

MARC_41061-41062:1087398437:1 (e-PCR)
- UniSTS:471573

G67375 (e-PCR)
- UniSTS:186393

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit gamma-3

Names: AMP-activated protein kinase gamma subunit; AMPK gamma3; AMPK subunit gamma-3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214077.1 → NP_999242.1 5'-AMP-activated protein kinase subunit gamma-3

See identical proteins and their annotated locations for NP_999242.1

Status: PROVISIONAL

Source sequence(s)

AF214520

UniProtKB/Swiss-Prot

Q53ZT5, Q6WZ89, Q9MYP4

UniProtKB/TrEMBL

A0A4X1UIE8

Related

ENSSSCP00000028985.3, ENSSSCT00000033825.4

Conserved Domains (3) summary

COG0517
Location:382 → 499

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:226 → 355

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:382 → 501

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...