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INHBA inhibin subunit beta A [ Sus scrofa (pig) ]

Gene ID: 397093, updated on 17-Aug-2024

Summary

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Official Symbol
INHBAprovided by VGNC
Official Full Name
inhibin subunit beta Aprovided by VGNC
Primary source
VGNC:VGNC:89133
See related
Ensembl:ENSSSCG00000035077
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in ovary (RPKM 6.3), liver (RPKM 6.0) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See INHBA in Genome Data Viewer
Location:
chromosome: 18
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (53115379..53117128)
106 current Sscrofa11.1 (GCF_000003025.6) 18 NC_010460.4 (52889684..52909260)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (55481493..55483255)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 18 NC_010460.3 (57997858..58017387)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 88 Neighboring gene N-alpha-acetyltransferase 38, NatC auxiliary subunit Neighboring gene uncharacterized LOC102158553 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene uncharacterized LOC100525078 Neighboring gene ring finger protein 227

Chromosome 18 - NC_010460.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110257601 Neighboring gene uncharacterized LOC102167258 Neighboring gene uncharacterized LOC110257548 Neighboring gene uncharacterized LOC110257602

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Expression of INHβA and INHβB proteins in porcine oocytes cultured in vitro is dependent on the follicle size. Kempisty B, et al. Zygote, 2015 Apr. PMID 24134883, Free PMC Article
  2. Expression and cellular distribution of INHA and INHB before and after in vitro cultivation of porcine oocytes isolated from follicles of different size. Kempisty B, et al. J Biomed Biotechnol, 2012. PMID 23226944, Free PMC Article
  3. Production of inhibin A and inhibin B in boars: changes in testicular and circulating levels of dimeric inhibins and characterization of inhibin forms during testis growth. Ohnuma K, et al. Domest Anim Endocrinol, 2007 Nov. PMID 17010559
  4. Isolation and characterization of native activin B. Nakamura T, et al. J Biol Chem, 1992 Aug 15. PMID 1644823
  5. Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta. Mason AJ, et al. Nature, 1985 Dec 19-1986 Jan 1. PMID 2417121

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An increased expression of Inhibin-beta A was found in oocytes collected from large and medium follicles compared with small follicles before or after in oocyte vitro maturation.
    Title: Expression of INHβA and INHβB proteins in porcine oocytes cultured in vitro is dependent on the follicle size.
  2. INHA and INHB expression and cellular localization in porcine oocytes were studied.
    Title: Expression and cellular distribution of INHA and INHB before and after in vitro cultivation of porcine oocytes isolated from follicles of different size.
  3. results indicated that boar testis produces inhibin A and inhibin B during the infantile period but inhibin A is the predominant form towards puberty and molecular weight forms of inhibin and the sites of production change with testicular development
    Title: Production of inhibin A and inhibin B in boars: changes in testicular and circulating levels of dimeric inhibins and characterization of inhibin forms during testis growth.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inhibin beta A chain
Names
activin beta-A chain
inhibin beta A subunit
inhibin beta-subunit
inhibin, beta A (activin A, activin AB alpha polypeptide)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214028.1 → NP_999193.1  inhibin beta A chain precursor

    See identical proteins and their annotated locations for NP_999193.1

    Status: PROVISIONAL

    Source sequence(s)
    X03266
    UniProtKB/Swiss-Prot
    P03970
    UniProtKB/TrEMBL
    A0A8D0IWS1
    Related
    ENSSSCP00000051495.1, ENSSSCT00000061917.2
    Conserved Domains (2) summary
    smart00204
    Location:319 → 424
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56 → 291
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    53115379..53117128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010460.4 Reference Sscrofa11.1 Primary Assembly

    Range
    52889684..52909260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03970.1 GenPept UniProtKB/Swiss-Prot:P03970

Gene LinkOut

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