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DUOX2 dual oxidase 2 [ Sus scrofa (pig) ]

Gene ID: 397060, updated on 17-Aug-2024

Summary

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Official Symbol
DUOX2provided by VGNC
Official Full Name
dual oxidase 2provided by VGNC
Primary source
VGNC:VGNC:103086
See related
Ensembl:ENSSSCG00000004678
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in lung (RPKM 11.9), mixtures (RPKM 2.3) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See DUOX2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (126620468..126641406)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (141221502..141241329)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase maturation factor 2 Neighboring gene sorbitol dehydrogenase Neighboring gene telomere repeat binding bouquet formation protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Dual oxidase2 is expressed all along the digestive tract. El Hassani RA, et al. Am J Physiol Gastrointest Liver Physiol, 2005 May. PMID 15591162
  2. Targeting of the dual oxidase 2 N-terminal region to the plasma membrane. Morand S, et al. J Biol Chem, 2004 Jul 16. PMID 15150274
  3. Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles. Morand S, et al. Endocrinology, 2003 Apr. PMID 12639906
  4. Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes. Morand S, et al. Endocrinology, 2003 Feb. PMID 12538618
  5. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. Dupuy C, et al. J Biol Chem, 1999 Dec 24. PMID 10601291

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual oxidase 2
Names
NADH/NADPH thyroid oxidase p138-tox
NP_999164.2
XP_020938217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213999.2 → NP_999164.2  dual oxidase 2 precursor

    See identical proteins and their annotated locations for NP_999164.2

    Status: PROVISIONAL

    Source sequence(s)
    AF547267
    UniProtKB/Swiss-Prot
    Q8HZK2, Q9TT98
    UniProtKB/TrEMBL
    A0A4X1VGQ6
    Related
    ENSSSCP00000049869.2, ENSSSCT00000046180.3
    Conserved Domains (6) summary
    cd06186
    Location:1271 → 1545
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38 → 594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824 → 885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1085 → 1229
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:36 → 549
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:824 → 884
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    126620468..126641406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021082558.1 → XP_020938217.1  dual oxidase 2 isoform X1

    UniProtKB/TrEMBL
    A0A287B129, A0A8D0SD24, A0A8D0ZFJ5
    Conserved Domains (5) summary
    cd06186
    Location:1183 → 1457
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:1 → 506
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:736 → 797
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:769 → 841
    EF-hand_7; EF-hand domain pair
    cl26813
    Location:995 → 1313
    PLN02844; oxidoreductase/ferric-chelate reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HZK2.2 GenPept UniProtKB/Swiss-Prot:Q8HZK2

Gene LinkOut

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Research Materials