CD163 CD163 molecule [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CD163provided by VGNC
Official Full Name: CD163 moleculeprovided by VGNC
Primary source: VGNC:VGNC:112737
See related: Ensembl:ENSSSCG00000033146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in lung (RPKM 232.1), spleen (RPKM 75.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: chromosome: 5

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	5	NC_010447.5 (63300200..63334497)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	Unplaced Scaffold	NW_003539177.1 (5..471)

Chromosome 5 - NC_010447.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations within scavenger receptor cysteine-rich (SRCR) protein domain 5 of porcine CD163 involved in infection with porcine reproductive and respiratory syndrome virus (PRRS).
Title: Mutations within scavenger receptor cysteine-rich (SRCR) protein domain 5 of porcine CD163 involved in infection with porcine reproductive and respiratory syndrome virus (PRRS).
Generation of CD163-edited pig via electroporation of the CRISPR/Cas9 system into porcine in vitro-fertilized zygotes.
Title: Generation of CD163-edited pig via electroporation of the CRISPR/Cas9 system into porcine in vitro-fertilized zygotes.
Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection.
Title: Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection.
The expression of TLR2, Siglec-3 and CD163 on peripheral blood monocytes is significantly higher during H. parasuis-induced sepsis than before infection.
Title: TLR2, Siglec-3 and CD163 expressions on porcine peripheral blood monocytes are increased during sepsis caused by Haemophilus parasuis.
The frequency and median fluorescence intensity (MFI) of CD163 within pulmonary alveolar macrophages were much lower in porcine reproductive and respiratory syndrome virus Lena-infected pigs than in 3249-infected pigs.
Title: Virulent Lena strain induced an earlier and stronger downregulation of CD163 in bronchoalveolar lavage cells.
decrease of CD163(+) cells appears to be associated to porcine reproductive and respiratory syndrome virus replication and cell death
Title: Kinetics of the expression of CD163 and CD107a in the lung and tonsil of pigs after infection with PRRSV-1 strains of different virulence.
We used targeted pooled sequencing of the exons of CD163 to detect sequence variants in 35,000 pigs of diverse genetic background.Using a deep survey of sequence variation in the CD163 gene in domestic pigs, we found no potential knockout variants. The CD163 gene was moderately intolerant to variation and showed evidence of positive selection in the pig lineage, but no evidence of recent selective sweeps during breeding.
Title: Sequence variation, evolutionary constraint, and selection at the CD163 gene in pigs.
Study investigated the association of three CD163 polymorphisms with host immune responses following PRRSV challenge and also analyzed the combined effects of the CD163 SNPs. The most significant associations were found with the c.2509G>C, c.2638A>G and c.3534C>T polymorphisms.
Title: Polymorphisms in the porcine CD163 associated with response to PRRSV infection.
deletion of Exon 7 of the CD163 gene, encoding SRCR5 had no adverse effects in pigs and these animals showed complete resistance to viral infection by the positive-strand RNA PRRS virus
Title: Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.
CD163 is not necessary for infection with African swine fever virus.
Title: Genetically edited pigs lacking CD163 show no resistance following infection with the African swine fever virus isolate, Georgia 2007/1.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Gene Ontology Provided by RefSeq

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: scavenger receptor cysteine-rich type 1 protein M130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213976.1 → NP_999141.1 scavenger receptor cysteine-rich type 1 protein M130 precursor

See identical proteins and their annotated locations for NP_999141.1

Status: PROVISIONAL

Source sequence(s)

AJ311716

UniProtKB/TrEMBL

J9T3F8

Related

ENSSSCP00000053212.3, ENSSSCT00000044319.3

Conserved Domains (2) summary

smart00202
Location:713 → 813

SR; Scavenger receptor Cys-rich

pfam00530
Location:928 → 1023

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010447.5 Reference Sscrofa11.1 Primary Assembly

Range

63300200..63334497

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021091121.1 → XP_020946780.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X2

UniProtKB/TrEMBL

A0A4X1TVA7, A0A8D0R838, A0A8D1B1L8

Conserved Domains (1) summary

smart00202
Location:718 → 818

SR; Scavenger receptor Cys-rich
XM_021091120.1 → XP_020946779.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X1

UniProtKB/TrEMBL

A0A287A807

Related

ENSSSCP00000040119.3, ENSSSCT00000037917.3

Conserved Domains (1) summary

smart00202
Location:718 → 818

SR; Scavenger receptor Cys-rich
XM_021091123.1 → XP_020946782.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X4

UniProtKB/TrEMBL

A0A8D0LPT6, A0A8D0WE19, A0A8D1INW0

Related

ENSSSCP00000049232.2, ENSSSCT00000049020.2

Conserved Domains (1) summary

smart00202
Location:604 → 704

SR; Scavenger receptor Cys-rich
XM_021091122.1 → XP_020946781.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X3

UniProtKB/TrEMBL

A0A4X1TUM2, A0A8D1INW0

Conserved Domains (1) summary

smart00202
Location:604 → 704

SR; Scavenger receptor Cys-rich