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ITGB1 integrin subunit beta 1 [ Sus scrofa (pig) ]

Gene ID: 397019, updated on 17-Aug-2024

Summary

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Official Symbol
ITGB1provided by VGNC
Official Full Name
integrin subunit beta 1provided by VGNC
Primary source
VGNC:VGNC:96381
See related
Ensembl:ENSSSCG00000011101
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
CD29
Expression
Ubiquitous expression in lung (RPKM 93.5), spleen (RPKM 54.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See ITGB1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 10 NC_010452.4 (56078393..56130608, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 10 NC_010452.3 (61450695..61502941, complement)

Chromosome 10 - NC_010452.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106505183 Neighboring gene uncharacterized LOC102161032 Neighboring gene uncharacterized LOC110255702 Neighboring gene uncharacterized LOC106505184 Neighboring gene uncharacterized LOC110255704

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. [Analysis of association between CRS-PCR polymorphisms of integrin β1 gene and litter size in pigs]. Guo LY, et al. Yi Chuan, 2012 Jul. PMID 22805214
  2. Nanostructure and β1-integrin distribution analysis of pig's spermatogonial stem cell by atomic force microscopy. Li S, et al. Gene, 2012 Mar 10. PMID 22237019
  3. Verotoxin 2 enhances adherence of enterohemorrhagic Escherichia coli O157:H7 to intestinal epithelial cells and expression of {beta}1-integrin by IPEC-J2 cells. Liu B, et al. Appl Environ Microbiol, 2010 Jul. PMID 20453145, Free PMC Article
  4. Molecular cloning and characterization of the pig homologue to human CD29, the integrin beta1 subunit. Jiménez-Marín A, et al. Transplantation, 2000 Aug 27. PMID 10972224
  5. Ontogeny of elongation and gene expression in the early developing porcine conceptus. Yelich JV, et al. Biol Reprod, 1997 Nov. PMID 9369195

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggested that the effect of G allele of integrin beta1 gene on litter size is significant in Large White and Landrace.
    Title: [Analysis of association between CRS-PCR polymorphisms of integrin β1 gene and litter size in pigs].
  2. beta1-integrin antigen-antibody interactions and the distribution of beta1-integrin protein on spermatogonial stem cell membrane were demonstrated using atomic force microscopy
    Title: Nanostructure and β1-integrin distribution analysis of pig's spermatogonial stem cell by atomic force microscopy.
  3. Verotoxin 2 enhances adherence of enterohemorrhagic Escherichia coli O157:H7 to intestinal epithelial cells and expression of {beta}1-integrin by IPEC-J2 cells.
    Title: Verotoxin 2 enhances adherence of enterohemorrhagic Escherichia coli O157:H7 to intestinal epithelial cells and expression of {beta}1-integrin by IPEC-J2 cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-X3-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables collagen binding involved in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibronectin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin beta-1
Names
VLA-4 subunit beta
fibronectin receptor subunit beta
integrin beta-1 subunit
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213968.1 → NP_999133.1  integrin beta-1 precursor

    See identical proteins and their annotated locations for NP_999133.1

    Status: PROVISIONAL

    Source sequence(s)
    AF192528
    UniProtKB/Swiss-Prot
    Q9GLP0
    UniProtKB/TrEMBL
    A0A8D0QG65
    Related
    ENSSSCP00000030775.3, ENSSSCT00000035813.4
    Conserved Domains (3) summary
    pfam00362
    Location:34 → 464
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010452.4 Reference Sscrofa11.1 Primary Assembly

    Range
    56078393..56130608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013980285.2 → XP_013835739.1  integrin beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A4X1TP89, A0A8D0IYA9, K7GNY7
    Related
    ENSSSCP00000029594.3, ENSSSCT00000034074.4
    Conserved Domains (3) summary
    pfam00362
    Location:34 → 464
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 796
    Integrin_b_cyt; Integrin beta cytoplasmic domain

  2. XM_021064065.1 → XP_020919724.1  integrin beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A480NJR9, A0A8D0MB61, A0A8D1SGV8, A0A8D1STG6
    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07974
    Location:599 → 630
    EGF_2; EGF-like domain
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 777
    Integrin_b_cyt; Integrin beta cytoplasmic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GLP0.1 GenPept UniProtKB/Swiss-Prot:Q9GLP0

Gene LinkOut

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