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GULO gulonolactone (L-) oxidase [ Sus scrofa (pig) ]

Gene ID: 396759, updated on 17-Aug-2024

Summary

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Official Symbol
GULOprovided by VGNC
Official Full Name
gulonolactone (L-) oxidaseprovided by VGNC
Primary source
VGNC:VGNC:109148
See related
Ensembl:ENSSSCG00000009667
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in liver (RPKM 69.9) and mixtures (RPKM 24.8) See more
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Genomic context

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See GULO in Genome Data Viewer
Location:
chromosome: 14
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (11299858..11332892)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (12480095..12512560)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 2 beta Neighboring gene cholinergic receptor nicotinic alpha 2 subunit Neighboring gene epoxide hydrolase 2 Neighboring gene uncharacterized LOC106508065 Neighboring gene clusterin Neighboring gene scavenger receptor class A member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs. Hasan L, et al. Mamm Genome, 2004 Apr. PMID 15112110
  2. The L-gulono-gamma-lactone oxidase gene (GULO) which is a candidate for vitamin C deficiency in pigs maps to chromosome 14. Hasan L, et al. Anim Genet, 1999 Aug. PMID 10467707
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables D-arabinono-1,4-lactone oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
L-gulonolactone oxidase
Names
GLO
L-gulono-gamma-lactone oxidase
LGO
NP_001123420.1
XP_020927730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129948.1 → NP_001123420.1  L-gulonolactone oxidase

    See identical proteins and their annotated locations for NP_001123420.1

    Status: PROVISIONAL

    Source sequence(s)
    AF440259
    UniProtKB/Swiss-Prot
    Q8HXW0, Q9N1U4
    UniProtKB/TrEMBL
    A0A480RSW6, A0A8D0Z5V1
    Related
    ENSSSCP00000010324.4, ENSSSCT00000010600.5
    Conserved Domains (3) summary
    TIGR01678
    Location:7 → 432
    FAD_lactone_ox; sugar 1,4-lactone oxidases
    pfam01565
    Location:21 → 156
    FAD_binding_4; FAD binding domain
    pfam04030
    Location:180 → 438
    ALO; D-arabinono-1,4-lactone oxidase

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    11299858..11332892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021072071.1 → XP_020927730.1  L-gulonolactone oxidase isoform X1

    UniProtKB/TrEMBL
    A0A8D1W6W1
    Related
    ENSSSCP00000072209.1, ENSSSCT00000070279.2
    Conserved Domains (1) summary
    cl28071
    Location:2 → 410
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HXW0.3 GenPept UniProtKB/Swiss-Prot:Q8HXW0

Gene LinkOut

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Molecular Biology Databases
Research Materials