AGRN agrin [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: AGRNprovided by CGNC
Official Full Name: agrinprovided by CGNC
Primary source: CGNC:1448
See related: Ensembl:ENSGALG00010021766
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HSPG
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 21

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (2701837..2765473, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (2733755..2797606, complement)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development
Title: Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development.
The study shows that the most C-terminal cysteine residue of N-terminal agrin domain(Cys123) forms an interdomain disulfide bond with the FOLN subdomain of the follistatin-like module.
Title: An interdomain disulfide bridge links the NtA and first FS domain in agrin.
different regions within the agrin protein are responsible for synapse formation at the neuromuscular junction and for process formation in central nervous system neurons
Title: The process-inducing activity of transmembrane agrin requires follistatin-like domains.
Association of TM-agrin with lipid rafts results in the phosphorylation and activation of the Src family kinase Fyn and subsequently in the phosphorylation and activation of MAPK.
Title: Transmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.
Neural agrin might act as a trophic factor promoting the maturation of membrane electrical properties during differentiation, confirming the role of agrin as a general promoter of muscle development.
Title: Neural agrin changes the electrical properties of developing human skeletal muscle cells.
Data reveal a role for Wnts in post-synaptic assembly at the vertebrate NMJ by enhancing agrin function through Rac1 activation.
Title: Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin.
Agrin, released from neurons, controls the maturation of the excitation-contraction coupling mechanism and due to modulation of RyRs and L-type Ca(2+) channels. A role for neural agrin in skeletal muscle maturation is proposed.
Title: Neural agrin controls maturation of the excitation-contraction coupling mechanism in human myotubes developing in vitro.
Matrix interactions between exogenously supplied agrin and neuregulin-1 on the muscle surface provide a localized source of signaling factors needed to produce high densities of AChRs at neuromuscular junctions.
Title: Synergistic effects of neuregulin and agrin on muscle acetylcholine receptor expression.
Our results suggest that there are two distinct mechanisms for neurite outgrowth inhibition by agrin, one that is GAG-dependent and one that is GAG-independent
Title: Glycosaminoglycan-dependent and -independent inhibition of neurite outgrowth by agrin.
Agrin-induced ACHR aggregate formation requires cGMP and aggregate maturation requires activation of protein kinase G.
Title: Agrin-induced AChR aggregate formation requires cGMP and aggregate maturation requires activation of cGMP-dependent protein kinase.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables laminin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in receptor clustering	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: agrin

Names: heparan sulfate proteoglycan

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205527.4 → NP_990858.3 agrin precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000329

UniProtKB/TrEMBL

A0A8V0ZKC8

Related

ENSGALP00010031845.1, ENSGALT00010052939.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2701837..2765473 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015296845.4 → XP_015152331.3 agrin isoform X3

Related

ENSGALP00010031869.1, ENSGALT00010052963.1
XM_015296843.4 → XP_015152329.3 agrin isoform X2

Related

ENSGALP00010031863.1, ENSGALT00010052957.1
XM_015296842.4 → XP_015152328.3 agrin isoform X1

Related

ENSGALP00010031858.1, ENSGALT00010052952.1
XM_025142490.3 → XP_024998258.2 agrin isoform X4

UniProtKB/TrEMBL

A0A8V0ZF01, A0A8V0ZLZ8

Related

ENSGALP00010031837.1, ENSGALT00010052931.1

Conserved Domains (5) summary

smart00280
Location:392 → 437

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1045 → 1169

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1743 → 1773

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:694 → 734

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1293 → 1443

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...