APOA1 apolipoprotein AI [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: APOA1provided by CGNC
Official Full Name: apolipoprotein AIprovided by CGNC
Primary source: CGNC:49860
See related: Ensembl:ENSGALG00010024773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	24	NC_052555.1 (5166355..5167881, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	24	NC_052596.1 (5126550..5128052, complement)

Chromosome 24 - NC_052555.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcription of ApoA-I in chicken abdominal adipose tissue was regulated by DNA methylation.
Title: Promoter Methylation Regulates ApoA-I Gene Transcription in Chicken Abdominal Adipose Tissue.
The expression level of apoA I in group 2 (diseased) significantly decreased on d 60; the expression level of apoB100 slightly increased on d 30 in group 2, while it sharply decreased on d 60. Compared to group 1 (control), the expression level of apoB100 showed no significant difference in group 3 (protected).
Title: Abnormal histopathology, fat percent and hepatic apolipoprotein A I and apolipoprotein B100 mRNA expression in fatty liver hemorrhagic syndrome and their improvement by soybean lecithin.
these data suggest that apolipoprotein A-I may participate in a regulatory feedback mechanism with retinoic acid to control the action of retinoic acid on ocular targets during postnatal ocular growth.
Title: Identification of Apolipoprotein A-I as a Retinoic Acid-binding Protein in the Eye.
Mycoplasma gallisepticum surface lipoprotein pMGA interacts with host APOA1 during infection in chicken.
Title: Mycoplasma gallisepticum (HS strain) surface lipoprotein pMGA interacts with host apolipoprotein A-I during infection in chicken.
Expression of APO A1 begins very early throughout the lower layer (both hypoblast and endoblast). At later stages it is also expressed in the endoderm and its derivatives, the anterior intestinal portal endoderm and the growing liver bud.
Title: A differential screen for genes expressed in the extraembryonic endodermal layer of pre-primitive streak stage chick embryos reveals expression of Apolipoprotein A1 in hypoblast, endoblast and endoderm.
liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression
Title: Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression.
Apolipoprotein A-I (apoA-I) has the characteristics of a STOP signal both in the retina as well as in the fibrous sclera.
Title: Identification of apolipoprotein A-I as a "STOP" signal for myopia.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

APOA1sts1 (e-PCR), detects polymorphism
- UniSTS:279808

APOA1sts2 (e-PCR), detects polymorphism
- UniSTS:279809

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables high-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: apolipoprotein A-I

Names: apo-AI; apoA-I; apolipoprotein A1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205525.5 → NP_990856.1 apolipoprotein A-I preproprotein

See identical proteins and their annotated locations for NP_990856.1

Status: VALIDATED

Source sequence(s)

JAENSK010000341

UniProtKB/Swiss-Prot

P08250

Related

ENSGALP00010037235.1, ENSGALT00010060476.1

Conserved Domains (1) summary

pfam01442
Location:73 → 241

Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5166355..5167881 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015297971.4 → XP_015153457.1 apolipoprotein A-I isoform X1

Conserved Domains (1) summary

pfam01442
Location:73 → 209

Apolipoprotein; Apolipoprotein A1/A4/E domain