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POU2F1 POU class 2 homeobox 1 [ Gallus gallus (chicken) ]

Gene ID: 396463, updated on 17-Aug-2024

Summary

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Symbol
POU2F1provided by CGNC
Full Name
POU class 2 homeobox 1provided by CGNC
Primary source
CGNC:49816
See related
Ensembl:ENSGALG00010008180
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Oct-1; chOCT-1
Orthologs
human mouse all
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Genomic context

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See POU2F1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (91832511..91954337, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (91867130..91989007, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene cellular repressor of E1A stimulated genes 1 Neighboring gene CD247 molecule Neighboring gene uncharacterized LOC121109436 Neighboring gene uncharacterized LOC124417669 Neighboring gene dual specificity phosphatase 27 (putative) Neighboring gene glycoprotein A33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methyl CpG level at distal part of heat-shock protein promoter HSP70 exhibits epigenetic memory for heat stress by modulating recruitment of POU2F1-associated nucleosome-remodeling deacetylase (NuRD) complex. Kisliouk T, et al. J Neurochem, 2017 May. PMID 28278364
  2. Glutamate-induced octamer DNA binding and transcriptional control in cultured radial glia cells. López-Bayghen E, et al. J Neurochem, 2006 Aug. PMID 16787415
  3. Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution. Petryniak B, et al. Proc Natl Acad Sci U S A, 1990 Feb. PMID 1967834, Free PMC Article
  4. Cloning and characterization of the chick Oct binding factor OBF-1. Takechi S, et al. Biochim Biophys Acta, 2002 Sep 27. PMID 12359338
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that methylation level of a distal part of the HSP70 promoter and POU2F1 recruitment may reflect heat-stress-related epigenetic memory
    Title: Methyl CpG level at distal part of heat-shock protein promoter HSP70 exhibits epigenetic memory for heat stress by modulating recruitment of POU2F1-associated nucleosome-remodeling deacetylase (NuRD) complex.
  2. A glutamate-dependent increase in Oct-1 DNA binding and transcriptional activity is detected in retinal Muller glial cells, but not in cerebellar Bergmann glial cells.
    Title: Glutamate-induced octamer DNA binding and transcriptional control in cultured radial glia cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
POU domain, class 2, transcription factor 1
Names
NF-A1
OTF-1
octamer-binding protein (Oct-1)
octamer-binding protein 1
octamer-binding transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205472.1 → NP_990803.1  POU domain, class 2, transcription factor 1

    See identical proteins and their annotated locations for NP_990803.1

    Status: PROVISIONAL

    Source sequence(s)
    M29972
    UniProtKB/Swiss-Prot
    P15143
    UniProtKB/TrEMBL
    A0A8V0Y180
    Related
    ENSGALP00010011120.1, ENSGALT00010019572.1
    Conserved Domains (2) summary
    smart00352
    Location:274 → 348
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:378 → 431
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    91832511..91954337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040670481.1 → XP_040526415.1  POU domain, class 2, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XWS3, A0A8V0Y180
    Related
    ENSGALP00010011137.1, ENSGALT00010019589.1
    Conserved Domains (2) summary
    smart00352
    Location:327 → 401
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:428 → 484
    HOX; Homeodomain

  2. XM_040671296.2 → XP_040527230.1  POU domain, class 2, transcription factor 1 isoform X14

    UniProtKB/TrEMBL
    A0A8V0XSD0
    Conserved Domains (3) summary
    smart00352
    Location:180 → 254
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284 → 337
    Homeobox; Homeobox domain
    pfam19536
    Location:352 → 628
    POU2F1_C; POU domain, class 2, transcription factor 1 C-terminal

  3. XM_040671195.2 → XP_040527129.1  POU domain, class 2, transcription factor 1 isoform X13

    UniProtKB/TrEMBL
    A0A8V0XSD0
    Conserved Domains (2) summary
    smart00352
    Location:183 → 257
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:287 → 341
    Homeobox; Homeobox domain

  4. XM_046923714.1 → XP_046779670.1  POU domain, class 2, transcription factor 1 isoform X10

    UniProtKB/TrEMBL
    A0A8V0Y4Z9

  5. XM_046923847.1 → XP_046779803.1  POU domain, class 2, transcription factor 1 isoform X12

    UniProtKB/TrEMBL
    A0A8V0XSD0

  6. XM_040670939.2 → XP_040526873.1  POU domain, class 2, transcription factor 1 isoform X8

    UniProtKB/TrEMBL
    A0A8V0Y183
    Conserved Domains (2) summary
    smart00352
    Location:258 → 332
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:359 → 415
    HOX; Homeodomain

  7. XM_040670881.2 → XP_040526815.1  POU domain, class 2, transcription factor 1 isoform X7

    UniProtKB/TrEMBL
    A0A8V0Y183
    Conserved Domains (2) summary
    smart00352
    Location:261 → 335
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:362 → 418
    HOX; Homeodomain

  8. XM_040671048.2 → XP_040526982.1  POU domain, class 2, transcription factor 1 isoform X11

    UniProtKB/TrEMBL
    A0A8V0XSD0
    Conserved Domains (2) summary
    smart00352
    Location:238 → 312
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:339 → 395
    HOX; Homeodomain

  9. XM_015295902.4 → XP_015151388.1  POU domain, class 2, transcription factor 1 isoform X9

    UniProtKB/TrEMBL
    A0A8V0XSD0
    Conserved Domains (2) summary
    smart00352
    Location:241 → 315
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:345 → 399
    Homeobox; Homeobox domain

  10. XM_040671485.2 → XP_040527419.1  POU domain, class 2, transcription factor 1 isoform X17

    Conserved Domains (2) summary
    smart00352
    Location:298 → 372
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:399 → 455
    HOX; Homeodomain

  11. XM_015295876.4 → XP_015151362.1  POU domain, class 2, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XSF4, A0A8V0Y180
    Related
    ENSGALP00010011133.1, ENSGALT00010019585.1
    Conserved Domains (2) summary
    smart00352
    Location:298 → 372
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:402 → 456
    Homeobox; Homeobox domain

  12. XM_040671403.2 → XP_040527337.1  POU domain, class 2, transcription factor 1 isoform X16

    Conserved Domains (3) summary
    smart00352
    Location:301 → 375
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:405 → 458
    Homeobox; Homeobox domain
    pfam19536
    Location:473 → 604
    POU2F1_C; POU domain, class 2, transcription factor 1 C-terminal

  13. XM_015295868.4 → XP_015151354.1  POU domain, class 2, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y180
    Conserved Domains (2) summary
    smart00352
    Location:301 → 375
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:405 → 459
    Homeobox; Homeobox domain

  14. XM_040670804.2 → XP_040526738.1  POU domain, class 2, transcription factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8V0Y180
    Conserved Domains (2) summary
    smart00352
    Location:286 → 360
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:390 → 444
    Homeobox; Homeobox domain

  15. XM_040671349.2 → XP_040527283.1  POU domain, class 2, transcription factor 1 isoform X15

    UniProtKB/TrEMBL
    A0A8V0XSD0
    Conserved Domains (2) summary
    smart00352
    Location:168 → 242
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:269 → 325
    HOX; Homeodomain

  16. XM_025146987.3 → XP_025002755.1  POU domain, class 2, transcription factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XSB7, A0A8V0Y180
    Related
    ENSGALP00010011092.1, ENSGALT00010019544.1
    Conserved Domains (2) summary
    smart00352
    Location:286 → 360
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:390 → 444
    Homeobox; Homeobox domain

  17. XM_015295883.4 → XP_015151369.1  POU domain, class 2, transcription factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y180
    Conserved Domains (2) summary
    smart00352
    Location:289 → 363
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:393 → 447
    Homeobox; Homeobox domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    91867130..91989007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906943.1 → XP_046762899.1  POU domain, class 2, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XWS3, A0A8V0Y180

  2. XM_046906957.1 → XP_046762913.1  POU domain, class 2, transcription factor 1 isoform X14

    UniProtKB/TrEMBL
    A0A8V0XSD0
    Conserved Domains (3) summary
    smart00352
    Location:180 → 254
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284 → 337
    Homeobox; Homeobox domain
    pfam19536
    Location:352 → 628
    POU2F1_C; POU domain, class 2, transcription factor 1 C-terminal

  3. XM_046906956.1 → XP_046762912.1  POU domain, class 2, transcription factor 1 isoform X13

    UniProtKB/TrEMBL
    A0A8V0XSD0

  4. XM_046906953.1 → XP_046762909.1  POU domain, class 2, transcription factor 1 isoform X10

    UniProtKB/TrEMBL
    A0A8V0Y4Z9

  5. XM_046906955.1 → XP_046762911.1  POU domain, class 2, transcription factor 1 isoform X12

    UniProtKB/TrEMBL
    A0A8V0XSD0

  6. XM_046906951.1 → XP_046762907.1  POU domain, class 2, transcription factor 1 isoform X8

    UniProtKB/TrEMBL
    A0A8V0Y183

  7. XM_046906950.1 → XP_046762906.1  POU domain, class 2, transcription factor 1 isoform X7

    UniProtKB/TrEMBL
    A0A8V0Y183

  8. XM_046906954.1 → XP_046762910.1  POU domain, class 2, transcription factor 1 isoform X11

    UniProtKB/TrEMBL
    A0A8V0XSD0

  9. XM_046906952.1 → XP_046762908.1  POU domain, class 2, transcription factor 1 isoform X9

    UniProtKB/TrEMBL
    A0A8V0XSD0

  10. XM_046906960.1 → XP_046762916.1  POU domain, class 2, transcription factor 1 isoform X17

  11. XM_046906945.1 → XP_046762901.1  POU domain, class 2, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XSF4, A0A8V0Y180

  12. XM_046906959.1 → XP_046762915.1  POU domain, class 2, transcription factor 1 isoform X16

    Conserved Domains (3) summary
    smart00352
    Location:301 → 375
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:405 → 458
    Homeobox; Homeobox domain
    pfam19536
    Location:473 → 604
    POU2F1_C; POU domain, class 2, transcription factor 1 C-terminal

  13. XM_046906944.1 → XP_046762900.1  POU domain, class 2, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y180

  14. XM_046906949.1 → XP_046762905.1  POU domain, class 2, transcription factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8V0Y180

  15. XM_046906958.1 → XP_046762914.1  POU domain, class 2, transcription factor 1 isoform X15

    UniProtKB/TrEMBL
    A0A8V0XSD0

  16. XM_046906948.1 → XP_046762904.1  POU domain, class 2, transcription factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XSB7, A0A8V0Y180

  17. XM_046906947.1 → XP_046762903.1  POU domain, class 2, transcription factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y180
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15143.1 GenPept UniProtKB/Swiss-Prot:P15143

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