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PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial [ Gallus gallus (chicken) ]

Gene ID: 396457, updated on 10-Oct-2024

Summary

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Symbol
PCK2provided by CGNC
Full Name
phosphoenolpyruvate carboxykinase 2, mitochondrialprovided by CGNC
Primary source
CGNC:49813
See related
Ensembl:ENSGALG00010003862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PEPCK-M
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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Genomic context

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See PCK2 in Genome Data Viewer
Location:
chromosome: 35
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 35 NC_052566.1 (287074..313884, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 35 Unlocalized Scaffold NW_024096213.1 (213461..237793)

Chromosome 35 - NC_052566.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 1 Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene uncharacterized LOC112531456 Neighboring gene polyadenylate-binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into the mechanism of PEPCK catalysis. Holyoak T, et al. Biochemistry, 2006 Jul 11. PMID 16819824
  2. Alleles of cytosolic phosphoenolpyruvate carboxykinase (PEPCK): trait association and interaction with mitochondrial PEPCK in a strain of White Leghorn chickens. Parsanejad R, et al. Poult Sci, 2003 Nov. PMID 14653465
  3. Mitochondrial PEPCK: a highly polymorphic gene with alleles co-selected with Marek's disease resistance in chickens. Li S, et al. Anim Genet, 1998 Oct. PMID 9800330
  4. The promoter regulatory regions of the genes for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken and the rat have different species-specific roles in gluconeogenesis. Savon SP, et al. J Nutr, 1997 Feb. PMID 9039828
  5. Expression of the genes for the mitochondrial and cytosolic forms of phosphoenolpyruvate carboxykinase in avian liver during development. Savon S, et al. Biol Neonate, 1993. PMID 8399801

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that aryl hydrocarbon receptor (AHR) enhances phosphoenolpyruvate carboxykinase (PEPCK) ADP-ribosylation through TiPARP TiPARP (TCDD-inducible poly(ADP-ribose) polymerase).
    Title: Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).
  2. The three structures of the mitochondrial isoform of PEPCK reported provide the first observations of the structure of the mitochondrial isoform and insight into the mechanism of catalysis mediated by this enzyme.
    Title: Structural insights into the mechanism of PEPCK catalysis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphoenolpyruvate carboxykinase (GTP) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycerol biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in propionate catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Names
phosphoenolpyruvate carboxylase
NP_990801.2
XP_046761006.1
XP_046761007.1
XP_046761008.1
XP_046761009.1
XP_046761010.1
XP_046761011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205470.2 → NP_990801.2  phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    BG712445, BI391254, BU119450, BU317380, CO422454, J05419
    UniProtKB/TrEMBL
    A0A8V0XKH8

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052566.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    287074..313884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046905055.1 → XP_046761011.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X4

  2. XM_046905050.1 → XP_046761006.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHS6
    Related
    ENSGALP00010005284.1, ENSGALT00010008952.1

  3. XM_046905053.1 → XP_046761009.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X4

  4. XM_046905052.1 → XP_046761008.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8V0XAY3
    Related
    ENSGALP00010005282.1, ENSGALT00010008950.1

  5. XM_046905051.1 → XP_046761007.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2

    Related
    ENSGALP00010005276.1, ENSGALT00010008944.1

  6. XM_046905054.1 → XP_046761010.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NW_024096213.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    213461..237793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21642.2 GenPept UniProtKB/Swiss-Prot:P21642

Gene LinkOut

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