U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PKLR pyruvate kinase, liver and RBC [ Gallus gallus (chicken) ]

Gene ID: 396456, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Symbol
PKLRprovided by CGNC
Full Name
pyruvate kinase, liver and RBCprovided by CGNC
Primary source
CGNC:1412
See related
Ensembl:ENSGALG00010021110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PKM; PKM2
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PKLR in Genome Data Viewer
Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (1607490..1624773, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (1481253..1500490, complement)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene myosin IXA Neighboring gene SUMO/sentrin peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2 Neighboring gene microRNA 6660 Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene CUGBP Elav-like family member 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Primary structure of chicken muscle pyruvate kinase mRNA. Lonberg N, et al. Proc Natl Acad Sci U S A, 1983 Jun. PMID 6574503, Free PMC Article
  2. Intron/exon structure of the chicken pyruvate kinase gene. Lonberg N, et al. Cell, 1985 Jan. PMID 2981634
  3. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article
  4. Conserved BK channel-protein interactions reveal signals relevant to cell death and survival. Sokolowski B, et al. PLoS One, 2011. PMID 22174833, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
pyruvate kinase PKM
Names
pyruvate kinase M1/2
pyruvate kinase muscle isozyme
pyruvate kinase, muscle
NP_990800.1
XP_015134281.1
XP_015134282.1
XP_025009576.1
XP_046754900.1
XP_046754901.1
XP_046780567.1
XP_046780568.1
XP_046780569.1
XP_046780570.1
XP_046780571.1
XP_046780572.1
XP_046780573.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205469.2 → NP_990800.1  pyruvate kinase PKM

    See identical proteins and their annotated locations for NP_990800.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000245
    UniProtKB/Swiss-Prot
    P00548
    Related
    ENSGALP00010030307.1, ENSGALT00010051116.1
    Conserved Domains (2) summary
    cd00288
    Location:41 → 529
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:42 → 526
    pyruv_kin; pyruvate kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1607490..1624773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015278795.4 → XP_015134281.1  pyruvate kinase PKM isoform X3

    UniProtKB/TrEMBL
    F1NW43
    Related
    ENSGALP00010030300.1, ENSGALT00010051109.1
    Conserved Domains (1) summary
    cd00288
    Location:41 → 529
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  2. XM_025153808.3 → XP_025009576.1  pyruvate kinase PKM isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZG91
    Related
    ENSGALP00010030297.1, ENSGALT00010051106.1
    Conserved Domains (1) summary
    cd00288
    Location:61 → 549
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  3. XM_015278796.4 → XP_015134282.1  pyruvate kinase PKM isoform X1

    Conserved Domains (2) summary
    cd00288
    Location:61 → 549
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:62 → 546
    pyruv_kin; pyruvate kinase

  4. XM_046898945.1 → XP_046754901.1  pyruvate kinase PKM isoform X1

  5. XM_046898944.1 → XP_046754900.1  pyruvate kinase PKM isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1481253..1500490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924612.1 → XP_046780568.1  pyruvate kinase PKM isoform X5

  2. XM_046924611.1 → XP_046780567.1  pyruvate kinase PKM isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZGA1

  3. XM_046924617.1 → XP_046780573.1  pyruvate kinase PKM isoform X3

    UniProtKB/TrEMBL
    F1NW43

  4. XM_046924614.1 → XP_046780570.1  pyruvate kinase PKM isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZG91

  5. XM_046924613.1 → XP_046780569.1  pyruvate kinase PKM isoform X1

  6. XM_046924616.1 → XP_046780572.1  pyruvate kinase PKM isoform X1

  7. XM_046924615.1 → XP_046780571.1  pyruvate kinase PKM isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00548.2 GenPept UniProtKB/Swiss-Prot:P00548

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.