U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mnd minidiscs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39625, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mndprovided by FlyBase
Official Full Name
minidiscsprovided by FlyBase
Primary source
FLYBASE:FBgn0002778
Locus tag
Dmel_CG3297
See related
AllianceGenome:FB:FBgn0002778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3297; Dmel\CG3297; l(3)B5; l(3)ds-5; l(3)ds5; l(3)o52; l(3)SG29; md; Mnd; MND; SG29
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Involved in L-leucine import across plasma membrane. Predicted to be located in membrane. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; lung squamous cell carcinoma; and lysinuric protein intolerance. Orthologous to several human genes including SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mnd in Genome Data Viewer
Location:
71A4-71B1; 3-42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14985100..14991667)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14978200..14984767)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene Proteasome beta2 subunit Neighboring gene Reversion-inducing-cysteine-rich protein with kazal motifs

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A LAT1-Like Amino Acid Transporter Regulates Neuronal Activity in the Drosophila Mushroom Bodies. Delescluse J, et al. Cells, 2024 Aug 13. PMID 39195231, Free PMC Article
  2. minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation. Martin JF, et al. Mech Dev, 2000 Apr. PMID 10727855
  3. JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport. Ziegler AB, et al. Sci Rep, 2018 Jan 30. PMID 29382949, Free PMC Article
  4. Juvenile hormone signaling during oogenesis in Drosophila melanogaster. Dubrovsky EB, et al. Insect Biochem Mol Biol, 2002 Nov. PMID 12530223
  5. Multiple Allele Approach to the Study of Genes in DROSOPHILA MELANOGASTER That Are Involved in Imaginal Disc Development. Shearn A, et al. Genetics, 1978 Jun. PMID 17248839, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A LAT1-Like Amino Acid Transporter Regulates Neuronal Activity in the Drosophila Mushroom Bodies.
    Title: A LAT1-Like Amino Acid Transporter Regulates Neuronal Activity in the Drosophila Mushroom Bodies.
  2. Direct sensing of nutrients via a LAT1-like transporter Mnd in Drosophila insulin-producing cells has been demonstrated.
    Title: Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells.
  3. Data show that CG2791 and two Drosophila homologues of the mammalian CD98 light chains, Mnd (Minidiscs) and JhI-21, are required for normal levels of System L transport.
    Title: Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
minidiscs
Names
CG3297-PA
CG3297-PC
CG3297-PD
minidisks
mnd-PA
mnd-PC
mnd-PD

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14985100..14991667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168601.3 → NP_730006.1  minidiscs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730006.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMK0, Q7KUL6, Q9Y1A7
    Related
    FBpp0075379
    Conserved Domains (1) summary
    TIGR00911
    Location:22 → 496
    2A0308; L-type amino acid transporter

  2. NM_168600.3 → NP_730005.3  minidiscs, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730005.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMK0, Q7KUL6, Q9Y1A7
    Conserved Domains (1) summary
    TIGR00911
    Location:22 → 496
    2A0308; L-type amino acid transporter

  3. NM_079350.5 → NP_524074.1  minidiscs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524074.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMK0, Q7KUL6, Q9Y1A7
    Related
    FBpp0075380
    Conserved Domains (1) summary
    TIGR00911
    Location:22 → 496
    2A0308; L-type amino acid transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y1A7 Q9Y1A7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous