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VLDLR very low density lipoprotein receptor [ Gallus gallus (chicken) ]

Gene ID: 396154, updated on 17-Aug-2024

Summary

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Symbol
VLDLRprovided by CGNC
Full Name
very low density lipoprotein receptorprovided by CGNC
Primary source
CGNC:7730
See related
Ensembl:ENSGALG00010011837
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
LR8; VLDL; VTGR
Orthologs
human mouse all
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Genomic context

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See VLDLR in Genome Data Viewer
Location:
chromosome: Z
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (27059520..27074222)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (27059520..27074222)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Neighboring gene uncharacterized LOC107052277 Neighboring gene potassium voltage-gated channel modifier subfamily V member 2 Neighboring gene pumilio RNA binding family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family. Bujo H, et al. EMBO J, 1994 Nov 1. PMID 7957081, Free PMC Article
  2. The receptor for yolk lipoprotein deposition in the chicken oocyte. Barber DL, et al. J Biol Chem, 1991 Oct 5. PMID 1655760
  3. Pituitary progesterone receptor expression and plasma gonadotrophin concentrations in the reproductively dysfunctional mutant restricted ovulator chicken. Ocón-Grove OM, et al. Domest Anim Endocrinol, 2007 Apr. PMID 16677794
  4. Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes. Recheis B, et al. Cell Mol Life Sci, 2005 Aug. PMID 16041564, Free PMC Article
  5. The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brain. Stockinger W, et al. J Biol Chem, 1998 Nov 27. PMID 9822699

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LR8 binds, internalizes, and deposits the major yolk components in the ratio of their relative abundance in the accessible pool.
    Title: Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes.
  2. VLDLR transcripts are expressed in the tendon blastemas. Reelin inhibits tenogenic differentiation through VLDLR.
    Title: Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors.
  3. elevated circulating estrogen and/or decreased progesterone levels may have contributed to the upregulation of progesterone receptor mRNA and isoforms A and B in the pituitary gland of restricted ovulator hen, which have a point mutation in VLDLR.
    Title: Pituitary progesterone receptor expression and plasma gonadotrophin concentrations in the reproductively dysfunctional mutant restricted ovulator chicken.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
very low-density lipoprotein receptor
Names
VLDL receptor
VLDL-R
VTG receptor
very low density lipoprotein (VLDL)/vitellogenin receptor
vitellogenin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205229.2 → NP_990560.1  very low-density lipoprotein receptor precursor

    See identical proteins and their annotated locations for NP_990560.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000089
    UniProtKB/Swiss-Prot
    P98165
    Related
    ENSGALP00010016204.1, ENSGALT00010028290.1
    Conserved Domains (7) summary
    smart00192
    Location:210 → 242
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:525 → 567
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:414 → 444
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:51 → 85
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:255 → 291
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:588 → 628
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:378 → 412
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    27059520..27074222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015280076.4 → XP_015135562.1  very low-density lipoprotein receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y6D2
    Related
    ENSGALP00010016210.1, ENSGALT00010028303.1
    Conserved Domains (7) summary
    smart00192
    Location:210 → 242
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:525 → 567
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:414 → 444
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:51 → 85
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:255 → 291
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:588 → 628
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:378 → 412
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    27059520..27074222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934846.1 → XP_046790802.1  very low-density lipoprotein receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y6D2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98165.1 GenPept UniProtKB/Swiss-Prot:P98165

Gene LinkOut

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