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NF1 neurofibromin 1 [ Gallus gallus (chicken) ]

Gene ID: 396085, updated on 10-Oct-2024

Summary

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Symbol
NF1provided by CGNC
Full Name
neurofibromin 1provided by CGNC
Primary source
CGNC:49643
See related
Ensembl:ENSGALG00010029534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See NF1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
61
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (9485096..9581107, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (9222230..9317679, complement)

Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054812 Neighboring gene musashi RNA binding protein 2 Neighboring gene uncharacterized LOC121107289 Neighboring gene A-kinase anchoring protein 1 Neighboring gene ecotropic viral integration site 2A Neighboring gene ecotropic viral integration site 2B Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene WD repeat and SOCS box containing 1 Neighboring gene kinase suppressor of ras 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the sequence and embryonic expression of chicken neurofibromin mRNA. Schafer GL, et al. Mol Chem Neuropathol, 1993 Apr. PMID 8507305
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurofibromin
Names
neurofibromatosis-related protein NF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396680.1 → NP_001383609.1  neurofibromin

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000323
    UniProtKB/TrEMBL
    A0A8V1AKP1
    Conserved Domains (3) summary
    cd05130
    Location:1208 → 1561
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1593 → 1737
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1738 → 1847
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9485096..9581107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046902295.1 → XP_046758251.1  neurofibromin isoform X6

  2. XM_003642416.5 → XP_003642464.2  neurofibromin isoform X5

    UniProtKB/TrEMBL
    A0A8V1AMK4
    Conserved Domains (3) summary
    cd05130
    Location:1193 → 1525
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1557 → 1701
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1702 → 1811
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

  3. XM_415914.8 → XP_415914.3  neurofibromin isoform X4

    UniProtKB/TrEMBL
    A0A8V1AMK4
    Conserved Domains (3) summary
    cd05130
    Location:1193 → 1546
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1578 → 1722
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1723 → 1832
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

  4. XM_040650554.2 → XP_040506488.1  neurofibromin isoform X1

    UniProtKB/TrEMBL
    A0A8V1ADH8, A0A8V1AKP1
    Related
    ENSGALP00010044085.1, ENSGALT00010071395.1
    Conserved Domains (3) summary
    cd05130
    Location:1193 → 1546
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1578 → 1722
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1723 → 1832
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

  5. XM_040650555.2 → XP_040506489.1  neurofibromin isoform X3

    UniProtKB/TrEMBL
    A0A8V1AKP1
    Related
    ENSGALP00010044084.1, ENSGALT00010071394.1
    Conserved Domains (3) summary
    cd05130
    Location:1208 → 1540
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1572 → 1716
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1717 → 1826
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

  6. XM_004946785.5 → XP_004946842.2  neurofibromin isoform X2

    UniProtKB/TrEMBL
    A0A8V1AMK4
    Conserved Domains (3) summary
    cd05130
    Location:1208 → 1561
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1593 → 1737
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1738 → 1847
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9222230..9317679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929917.1 → XP_046785873.1  neurofibromin isoform X6

  2. XM_040687709.2 → XP_040543643.1  neurofibromin isoform X5

    UniProtKB/TrEMBL
    A0A8V1AMK4
    Conserved Domains (3) summary
    cd05130
    Location:1193 → 1525
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1702 → 1811
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1576 → 1710
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  3. XM_040687708.2 → XP_040543642.1  neurofibromin isoform X4

    UniProtKB/TrEMBL
    A0A8V1AMK4
    Conserved Domains (3) summary
    cd05130
    Location:1193 → 1546
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1578 → 1722
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1723 → 1832
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

  4. XM_040687705.2 → XP_040543639.1  neurofibromin isoform X1

    UniProtKB/TrEMBL
    A0A8V1AKP1
    Conserved Domains (3) summary
    cd05130
    Location:1193 → 1546
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1578 → 1722
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1723 → 1832
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

  5. XM_040687707.2 → XP_040543641.1  neurofibromin isoform X3

    UniProtKB/TrEMBL
    A0A8V1AKP1
    Conserved Domains (3) summary
    cd05130
    Location:1208 → 1540
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00516
    Location:1572 → 1716
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd13313
    Location:1717 → 1826
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain

  6. XM_040687706.2 → XP_040543640.1  neurofibromin isoform X2

    UniProtKB/TrEMBL
    A0A8V1AMK4
    Conserved Domains (3) summary
    cd05130
    Location:1208 → 1561
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1738 → 1847
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1612 → 1746
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35608.1 GenPept UniProtKB/Swiss-Prot:P35608

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