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NR5A1 nuclear receptor subfamily 5 group A member 1 [ Gallus gallus (chicken) ]

Gene ID: 395960, updated on 10-Oct-2024

Summary

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Symbol
NR5A1provided by CGNC
Full Name
nuclear receptor subfamily 5 group A member 1provided by CGNC
Primary source
CGNC:49576
See related
Ensembl:ENSGALG00010028916
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SF-1; Ad4BP
Orthologs
human mouse all
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Genomic context

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See NR5A1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (10036794..10052644, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (9447237..9463085, complement)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 6 Neighboring gene proteasome subunit beta 7 Neighboring gene uncharacterized LOC112529977 Neighboring gene adhesion G protein-coupled receptor D2 Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene uncharacterized LOC107052170 Neighboring gene microRNA 181a-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sex difference in Ad4BP/SF-1 mRNA expression in the chick-embryo brain before gonadal sexual differentiation. Endo D, et al. Zoolog Sci, 2007 Sep. PMID 17960991
  2. Transcription of CYP19A1 is directly regulated by SF-1 in the theca cells of ovary follicles in chicken. Wang J, et al. Gen Comp Endocrinol, 2017 Jun 1. PMID 28347743
  3. Identification of male-biased microRNA-107 as a direct regulator for nuclear receptor subfamily 5 group A member 1 based on sexually dimorphic microRNA expression profiling from chicken embryonic gonads. Miao N, et al. Mol Cell Endocrinol, 2016 Jul 5. PMID 27036932
  4. Molecular cloning of chicken FTZ-F1-related orphan receptors. Kudo T, et al. Gene, 1997 Sep 15. PMID 9332374
  5. Evidence for activation of Amh gene expression by steroidogenic factor 1. Takada S, et al. Mech Dev, 2006 Jun. PMID 16806847

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SF-1 activates CYP19A1 mRNA expression via a conserved binding site in chicken ovary
    Title: Transcription of CYP19A1 is directly regulated by SF-1 in the theca cells of ovary follicles in chicken.
  2. over-expression of miR-107 directly inhibited nuclear receptor subfamily 5 group A member 1 (NR5a1), and its downstream cytochrome P450 family 19 subfamily A, polypeptide 1 (CYP19A1).
    Title: Identification of male-biased microRNA-107 as a direct regulator for nuclear receptor subfamily 5 group A member 1 based on sexually dimorphic microRNA expression profiling from chicken embryonic gonads.
  3. The mRNA of Ad4BP/SF-1 showed higher expression levels in the male brain than in the female brain at day 5.5 of incubation suggesting the involvement of a sex steroid signaling system in brain-autonomous sex differentiation
    Title: Sex difference in Ad4BP/SF-1 mRNA expression in the chick-embryo brain before gonadal sexual differentiation.
  4. SF1 plays a role in regulation of Amh expression in chickens
    Title: Evidence for activation of Amh gene expression by steroidogenic factor 1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
steroidogenic factor 1
Names
adrenal 4 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205077.2 → NP_990408.2  steroidogenic factor 1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000308
    UniProtKB/TrEMBL
    O42102, Q9PWI7
    Related
    ENSGALP00010043083.1, ENSGALT00010069957.1
    Conserved Domains (2) summary
    cd07070
    Location:227 → 464
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10036794..10052644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015279332.4 → XP_015134818.2  steroidogenic factor 1 isoform X1

    UniProtKB/TrEMBL
    O42102, Q9PWI7
    Conserved Domains (2) summary
    cd07070
    Location:227 → 464
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9447237..9463085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928755.1 → XP_046784711.1  steroidogenic factor 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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