SMO smoothened, frizzled class receptor [Gallus gallus (chicken)] - Gene

Summary

Symbol: SMOprovided by CGNC
Full Name: smoothened, frizzled class receptorprovided by CGNC
Primary source: CGNC:5983
See related: Ensembl:ENSGALG00010005498
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (1241744..1250136)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (1249107..1257478)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.
Title: A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.
Results indicate that the Smo-induced Galpha(i) activity plays an insignificant role in the regulation of Gli3 processing and Shh-regulated neural tube patterning.
Title: The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.

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General gene information

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Markers

ROS0114 (e-PCR), detects polymorphism
- UniSTS:280291

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables patched binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in commissural neuron axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein smoothened

Names: smoothened homolog; smoothened, frizzled family receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396428.1 → NP_001383357.1 protein smoothened

Status: VALIDATED

Source sequence(s)

AF019977, BM491700, BX276916, CD214888, DR425666

UniProtKB/TrEMBL

A0A1D5P8D7

Related

ENSGALP00010007706.1, ENSGALT00010013144.1

Conserved Domains (2) summary

cd07451
Location:57 → 187

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

cd15030
Location:211 → 541

7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors