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PAX6 paired box 6 [ Gallus gallus (chicken) ]

Gene ID: 395943, updated on 10-Oct-2024

Summary

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Symbol
PAX6provided by CGNC
Full Name
paired box 6provided by CGNC
Primary source
CGNC:49564
See related
Ensembl:ENSGALG00010023642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PAX-6
Orthologs
human mouse all
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Genomic context

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See PAX6 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (5398323..5415898, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (5363743..5381288, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene inner mitochondrial membrane peptidase subunit 1 Neighboring gene elongator acetyltransferase complex subunit 4 Neighboring gene reticulocalbin 1 Neighboring gene Wilms tumor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An analysis of anterior segment development in the chicken eye. Trejo-Reveles V, et al. Mech Dev, 2018 Apr. PMID 29526791
  2. A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo. Zhang SJ, et al. Dis Model Mech, 2016 Feb. PMID 26744353, Free PMC Article
  3. Proanthocyanidins Prevent High Glucose-Induced Eye Malformation by Restoring Pax6 Expression in Chick Embryo. Tan RR, et al. Nutrients, 2015 Aug 7. PMID 26262640, Free PMC Article
  4. Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Di Lullo E, et al. Development, 2011 Nov. PMID 22028031
  5. Stage-dependent expression of Pax6 in optic vesicle/cup regulates patterning genes through signaling molecules. Reza HM, et al. Differentiation, 2007 Oct. PMID 17381541

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network.
    Title: The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network.
  2. On the level of gene expression, GRIFIN's promoter was activated by transcription factor L-Maf alone and together with Pax6 like a crystallin gene, substantiating C-GRIFIN's status as lens-specific galectin.
    Title: Chicken GRIFIN: binding partners, developmental course of localization and activation of its lens-specific gene expression by L-Maf/Pax6.
  3. We performed expression analyses for a panel of known AS disorder genes, and showed that chick PAX6 was localized to cells of neural retina and surface ectoderm derived structures, displaying remarkable similarity to the mouse.
    Title: An analysis of anterior segment development in the chicken eye.
  4. Comparative functional analyses revealed that the neurogenic function of Pax6 is highly conserved in the developing mouse and chick pallium, whereas stage-specific binary functions of Pax6 in neurogenesis are unique to mouse neuronal progenitors, consistent with Pax6-dependent temporal regulation of Notch signaling. Pax6-dependent enhancer activity of Dbx1 is extensively conserved between mammals and chick.
    Title: Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.
  5. Study reports that promoter activity of PAX6 and metalloproteinase-9 increased as a result of glucocorticoid-stimulation in vitro. Findings indicate that excess prenatal glucocorticoid stimulation disturbs normal development of the cerebellum through mechanisms associated with reduced proliferation and accelerated maturation where PAX6 and metalloproteinase-9 play important roles.
    Title: Glucocorticoid Effects on Cerebellar Development in a Chicken Embryo Model: Exploring Changes in PAX6 and Metalloproteinase-9 After Exposure to Dexamethasone.
  6. suppression of the Pax6 gene is probably mediated by oxidative stress and could be a crucial target for the therapy of GDM-induced embryonic eye malformation
    Title: A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo.
  7. The key gene regulating eye development, Pax6, was down-regulated by high glucose. Proanthocyanidins could restore the suppressed expression of Pax6.
    Title: Proanthocyanidins Prevent High Glucose-Induced Eye Malformation by Restoring Pax6 Expression in Chick Embryo.
  8. The zinc-finger protein Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary.
    Title: Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord.
  9. Irx3 and Pax6 establish differential competence for Shh-mediated induction of GABAergic and glutamatergic neurons of the thalamus.
    Title: Irx3 and Pax6 establish differential competence for Shh-mediated induction of GABAergic and glutamatergic neurons of the thalamus.
  10. Mesendoderm-derived somatostatin promotes aPP identity in the overlying ectoderm by regulating Eya2 and nociceptin. Nociceptin controls its own expression and, together with somatostatin, the onset of Pax6, a key regulator of eye and olfactory fates.
    Title: Neuropeptides: developmental signals in placode progenitor formation.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
paired box protein Pax-6
Names
paired box gene 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397296.1 → NP_001384225.1  paired box protein Pax-6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    A0A8V0ZNJ7, A0A8V1A1B9
    Related
    ENSGALP00010034988.1, ENSGALT00010057606.1
    Conserved Domains (2) summary
    smart00351
    Location:4 → 142
    PAX; Paired Box domain
    pfam00046
    Location:228 → 281
    Homeobox; Homeobox domain

  2. NM_001397297.1 → NP_001384226.1  paired box protein Pax-6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Conserved Domains (2) summary
    smart00351
    Location:5 → 143
    PAX; Paired Box domain
    pfam00046
    Location:229 → 282
    Homeobox; Homeobox domain

  3. NM_001397298.1 → NP_001384227.1  paired box protein Pax-6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Conserved Domains (2) summary
    smart00351
    Location:4 → 128
    PAX; Paired Box domain
    pfam00046
    Location:214 → 267
    Homeobox; Homeobox domain

  4. NM_001397299.1 → NP_001384228.1  paired box protein Pax-6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Conserved Domains (2) summary
    smart00351
    Location:4 → 128
    PAX; Paired Box domain
    pfam00046
    Location:214 → 267
    Homeobox; Homeobox domain

  5. NM_001397301.1 → NP_001384230.1  paired box protein Pax-6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    A0A8V0ZNJ7, A0A8V0ZNK7
    Related
    ENSGALP00010034993.1, ENSGALT00010057618.1
    Conserved Domains (2) summary
    smart00351
    Location:4 → 128
    PAX; Paired Box domain
    pfam00046
    Location:214 → 267
    Homeobox; Homeobox domain

  6. NM_001397305.1 → NP_001384234.1  paired box protein Pax-6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    Conserved Domains (1) summary
    pfam00046
    Location:78 → 131
    Homeobox; Homeobox domain

  7. NM_001397308.1 → NP_001384237.1  paired box protein Pax-6 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    Conserved Domains (1) summary
    pfam00046
    Location:78 → 131
    Homeobox; Homeobox domain

  8. NM_205066.2 → NP_990397.1  paired box protein Pax-6 isoform 1

    See identical proteins and their annotated locations for NP_990397.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    A0A8V0ZNJ7, E1BXC6, O42348
    Conserved Domains (2) summary
    smart00351
    Location:4 → 142
    PAX; Paired Box domain
    pfam00046
    Location:228 → 281
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5398323..5415898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046941465.1 → XP_046797421.1  paired box protein Pax-6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZTT5
    Related
    ENSGALP00010034990.1, ENSGALT00010057610.1

  2. XM_046941463.1 → XP_046797419.1  paired box protein Pax-6 isoform X3

  3. XM_025150599.3 → XP_025006367.1  paired box protein Pax-6 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Conserved Domains (2) summary
    smart00351
    Location:5 → 143
    PAX; Paired Box domain
    pfam00046
    Location:229 → 282
    Homeobox; Homeobox domain

  4. XM_046941464.1 → XP_046797420.1  paired box protein Pax-6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZTT5

  5. XM_046941462.1 → XP_046797418.1  paired box protein Pax-6 isoform X2

  6. XM_025150598.3 → XP_025006366.1  paired box protein Pax-6 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Conserved Domains (2) summary
    smart00351
    Location:5 → 143
    PAX; Paired Box domain
    pfam00046
    Location:229 → 282
    Homeobox; Homeobox domain

  7. XM_025150604.3 → XP_025006372.1  paired box protein Pax-6 isoform X11

    Conserved Domains (3) summary
    pfam00046
    Location:148 → 200
    Homeobox; Homeobox domain
    pfam03999
    Location:133 → 284
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl21459
    Location:5 → 57
    HTH; Helix-turn-helix domains

  8. XM_025150603.3 → XP_025006371.1  paired box protein Pax-6 isoform X10

    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Conserved Domains (3) summary
    pfam00046
    Location:162 → 214
    Homeobox; Homeobox domain
    pfam03999
    Location:147 → 298
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl21459
    Location:5 → 71
    HTH; Helix-turn-helix domains

  9. XM_040700700.2 → XP_040556634.1  paired box protein Pax-6 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Related
    ENSGALP00010034982.1, ENSGALT00010057594.1
    Conserved Domains (2) summary
    smart00351
    Location:5 → 143
    PAX; Paired Box domain
    pfam00046
    Location:229 → 282
    Homeobox; Homeobox domain

  10. XM_046941466.1 → XP_046797422.1  paired box protein Pax-6 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZNK7

  11. XM_025150605.2 → XP_025006373.1  paired box protein Pax-6 isoform X9

    Conserved Domains (2) summary
    pfam00046
    Location:147 → 200
    Homeobox; Homeobox domain
    cl21459
    Location:4 → 56
    HTH; Helix-turn-helix domains

  12. XM_015286143.3 → XP_015141629.1  paired box protein Pax-6 isoform X8

    Conserved Domains (2) summary
    pfam00046
    Location:147 → 200
    Homeobox; Homeobox domain
    cl21459
    Location:4 → 56
    HTH; Helix-turn-helix domains

  13. XM_040700703.1 → XP_040556637.1  paired box protein Pax-6 isoform X7

    Conserved Domains (2) summary
    pfam00046
    Location:161 → 214
    Homeobox; Homeobox domain
    cl21459
    Location:4 → 70
    HTH; Helix-turn-helix domains

  14. XM_015286141.3 → XP_015141627.1  paired box protein Pax-6 isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZNJ7
    Conserved Domains (2) summary
    pfam00046
    Location:161 → 214
    Homeobox; Homeobox domain
    cl21459
    Location:4 → 70
    HTH; Helix-turn-helix domains

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5363743..5381288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917874.1 → XP_046773830.1  paired box protein Pax-6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZTT5

  2. XM_046917872.1 → XP_046773828.1  paired box protein Pax-6 isoform X3

  3. XM_046917870.1 → XP_046773826.1  paired box protein Pax-6 isoform X1

  4. XM_046917873.1 → XP_046773829.1  paired box protein Pax-6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZTT5

  5. XM_046917871.1 → XP_046773827.1  paired box protein Pax-6 isoform X2

  6. XM_046917869.1 → XP_046773825.1  paired box protein Pax-6 isoform X1

  7. XM_046917868.1 → XP_046773824.1  paired box protein Pax-6 isoform X1

  8. XM_046917875.1 → XP_046773831.1  paired box protein Pax-6 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZNK7

  9. XM_046917879.1 → XP_046773835.1  paired box protein Pax-6 isoform X9

  10. XM_046917878.1 → XP_046773834.1  paired box protein Pax-6 isoform X8

  11. XM_046917877.1 → XP_046773833.1  paired box protein Pax-6 isoform X7

  12. XM_046917876.1 → XP_046773832.1  paired box protein Pax-6 isoform X6

  13. XM_046917867.1 → XP_046773823.1  paired box protein Pax-6 isoform X12

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47237.1 GenPept UniProtKB/Swiss-Prot:P47237

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