GREM1 gremlin 1, DAN family BMP antagonist [Gallus gallus (chicken)] - Gene

Summary

Symbol: GREM1provided by CGNC
Full Name: gremlin 1, DAN family BMP antagonistprovided by CGNC
Primary source: CGNC:49499
See related: Ensembl:ENSGALG00010021611
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: Drm
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (30058437..30068310, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (30040109..30049959, complement)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Determination of the roles of GREM1 gene in granulosa cell proliferation and steroidogenesis of hen ovarian prehierarchical follicles.
Title: Determination of the roles of GREM1 gene in granulosa cell proliferation and steroidogenesis of hen ovarian prehierarchical follicles.
early stages of the GREM1-SHH-FGF signaling network are resistant to Chrdl1-overexpression, with normal formation of proximal limb structures, but later Bmp expression, impaired by ectopic CHRDL1, is essential for the correct complement of digits
Title: Autopodial development is selectively impaired by misexpression of chordin-like 1 in the chick limb.
Tgfbeta signaling negatively regulates the expression of the BMP-antagonist Gremlin in the early limb bud.
Title: Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.
Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.
Title: Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.
Drm (gremlin) could play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling
Title: Localized expression of drm/gremlin in the central nervous system of the chicken embryo.
Bone morphogenetic protein activity is necessary and sufficient for induction of Gremlin.
Title: Regulation of Gremlin expression in the posterior limb bud.
Shh-expressing cells and their descendants cannot express Gremlin; proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells which breaks down the Shh-Fgf4 loop and affects limb size
Title: The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables BMP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sequestering of BMP from receptor via BMP binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: gremlin-1

Names: Down-regulated by v-mos; gremlin 1 homolog, cysteine knot superfamily; gremlin 1, cysteine knot superfamily, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204978.3 → NP_990309.1 gremlin-1 precursor

See identical proteins and their annotated locations for NP_990309.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000215

UniProtKB/Swiss-Prot

O73755

Related

ENSGALP00010031376.1, ENSGALT00010052469.1

Conserved Domains (1) summary

pfam03045
Location:72 → 179

DAN; DAN domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

30058437..30068310 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025150591.3 → XP_025006359.1 gremlin-1 isoform X1

UniProtKB/Swiss-Prot

O73755

Related

ENSGALP00010031373.1, ENSGALT00010052466.1

Conserved Domains (1) summary

pfam03045
Location:72 → 179

DAN; DAN domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

30040109..30049959 complement

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GenBank, FASTA, Sequence Viewer (Graphics)